[HTML][HTML] Divergent landscapes of A-to-I editing in postmortem and living human brain
M Rodriguez de los Santos, BH Kopell… - nature …, 2024 - nature.com
Abstract Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA
modification within the brain. Yet, most research has relied on postmortem samples …
modification within the brain. Yet, most research has relied on postmortem samples …
[HTML][HTML] Divergent landscapes of A-to-I editing in postmortem and living human brain
Abstract Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA
modification within the brain. Yet, most research has relied on postmortem samples …
modification within the brain. Yet, most research has relied on postmortem samples …
Deciphering the functions and regulation of brain-enriched A-to-I RNA editing
JB Li, GM Church - Nature neuroscience, 2013 - nature.com
Abstract Adenosine-to-inosine (A-to-I) RNA editing, in which genomically encoded
adenosine is changed to inosine in RNA, is catalyzed by adenosine deaminase acting on …
adenosine is changed to inosine in RNA, is catalyzed by adenosine deaminase acting on …
Single-cell transcriptomics reveals specific RNA editing signatures in the human brain
While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is
under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of …
under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of …
Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system
AC Penn, A Balik, IH Greger - Frontiers in neuroscience, 2013 - frontiersin.org
The fine control of molecules mediating communication in the nervous system is key to
adjusting neuronal signaling during development and in maintaining the stability of …
adjusting neuronal signaling during development and in maintaining the stability of …
Comparative analysis of A-to-I editing in human and non-human primate brains reveals conserved patterns and context-dependent regulation of RNA editing
Abstract A-to-I RNA editing is an important process for generating molecular diversity in the
brain through modification of transcripts encoding several proteins important for neuronal …
brain through modification of transcripts encoding several proteins important for neuronal …
Dynamic regulation of RNA editing in human brain development and disease
RNA editing is increasingly recognized as a molecular mechanism regulating RNA activity
and recoding proteins. Here we surveyed the global landscape of RNA editing in human …
and recoding proteins. Here we surveyed the global landscape of RNA editing in human …
Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue
RNA editing is a feature of RNA maturation resulting in the formation of transcripts whose
sequence differs from the genome template. Brain RNA editing may be altered in …
sequence differs from the genome template. Brain RNA editing may be altered in …
Evolutionary and ontogenetic changes in RNA editing in human, chimpanzee, and macaque brains
Z Li, H Bammann, M Li, H Liang, Z Yan, YPP Chen… - Rna, 2013 - rnajournal.cshlp.org
Adenosine-to-inosine (A-to-I) substitutions are the most common type of RNA editing in
mammals. A-to-I RNA editing is particularly widespread in the brain and is known to play …
mammals. A-to-I RNA editing is particularly widespread in the brain and is known to play …
A-to-I RNA editing in the rat brain is age-dependent, region-specific and sensitive to environmental stress across generations
Background Adenosine-to-inosine (A-to-I) RNA editing is an epigenetic modification
catalyzed by adenosine deaminases acting on RNA (ADARs), and is especially prevalent in …
catalyzed by adenosine deaminases acting on RNA (ADARs), and is especially prevalent in …