The putative distinct diagnostic and pathogenic potential of aDNA-Ab subtypes, differing in
their affinity or epitope specificity, was subject of several studies with controversial results …

The structures of epitopes bound by autoantibodies against RNA–protein complexes have
been well-defined over several decades, but little is known of the clonality, immunoglobulin …

Objective The heterogeneity of systemic lupus erythematosus (SLE) constitutes clinical and
therapeutical challenges. We therefore studied whether unrecognized disease subgroups …

Publisher Summary The use of laboratory tests has greatly enhanced the ability to diagnose
systemic lupus erythematosus (SLE) and related disorders. Tests such as the antinuclear …

The objective was to determine the sensitivity and specificity of an automated
multiparameter line immunoassay system compared with other techniques for the …

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
antinuclear antibody (ANA) production. ANAs bind to DNA, RNA and complexes of proteins …

Differences in the fine specificity of ANTIâ•fiRo (SSâ•’A) in relation to the presence of other
precipitating autoantib Page 1 1563 DIFFERENCES IN THE FINE SPECIFICITY OF THE …

Autoantibodies have been used extensively as a useful biomarker in systemic lupus
erythematosus and other autoimmune rheumatic diseases. Antinuclear antibodies by …

The discovery of the 'lupus erythematosus (LE) cell'[1], as a phenomenon induced by
antibodies to nuclear antigens, led to the proposal that systemic lupus erythematosus (SLE) …

Objective To determine the frequency, the clinical and laboratory associations, and the
impact on survival of anti-dsDNA, anti-Sm, anti-nRNP, anti-Ro, and anti-La in patients with …