Characterization of the role of MrpC in Myxococcus xanthus developmental cell fate determination

V Bhardwaj - 2013 - archiv.ub.uni-marburg.de
Myxococcus xanthus is an excellent model system for multicellular prokaryotic behaviour
and Gram-negative differentiation. Under nutrient-limited conditions, the population enters a …

Transcription factor MrpC binds to promoter regions of hundreds of developmentally-regulated genes in Myxococcus xanthus

M Robinson, B Son, D Kroos, L Kroos - BMC genomics, 2014 - Springer
Background Myxococcus xanthus is a bacterium that undergoes multicellular development
when starved. Cells move to aggregation centers and form fruiting bodies in which cells …

MrpC, a CRP/Fnr homolog, functions as a negative autoregulator during the Myxococcus xanthus multicellular developmental program

M McLaughlin, V Bhardwaj, BE Feeley… - Molecular …, 2018 - Wiley Online Library
MrpC, a member of the CRP/Fnr superfamily of transcriptional regulators, plays a key role in
coordination of the multicellular developmental program in Myxococcus xanthus. Previous …

Ultrasensitive response of developing Myxococcus xanthus to the addition of nutrient medium correlates with the level of MrpC

Y Hoang, L Kroos - Journal of bacteriology, 2018 - Am Soc Microbiol
Upon depletion of nutrients, Myxococcus xanthus forms mounds on a solid surface. The
differentiation of rod-shaped cells into stress-resistant spores within mounds creates mature …

Genetic Studies of mrp, a Locus Essential for Cellular Aggregation and Sporulation of Myxococcus xanthus

H Sun, W Shi - Journal of bacteriology, 2001 - Am Soc Microbiol
Under starvation conditions, Myxococcus xanthus undergoes a complex developmental
process which includes cellular aggregation and sporulation. A transposon insertion mutant …

Mutation of self-binding sites in the promoter of the MrpC transcriptional regulator leads to asynchronous Myxococcus xanthus development

M McLaughlin, PI Higgs - Frontiers in Microbiology, 2023 - frontiersin.org
Introduction MrpC, a member of the CRP/Fnr transcription factor superfamily, is necessary to
induce and control the multicellular developmental program of the bacterium, Myxococcus …

Nutrient-regulated proteolysis of MrpC halts expression of genes important for commitment to sporulation during Myxococcus xanthus development

R Rajagopalan, L Kroos - Journal of bacteriology, 2014 - Am Soc Microbiol
Starved Myxococcus xanthus cells glide to aggregation centers and form fruiting bodies in
which rod-shaped cells differentiate into ovoid spores. Commitment to development was …

A protein Ser/Thr kinase cascade negatively regulates the DNA‐binding activity of MrpC, a smaller form of which may be necessary for the Myxococcus xanthus …

H Nariya, S Inouye - Molecular microbiology, 2006 - Wiley Online Library
The developmental process of Myxococcus xanthus is achieved by the expression of a
specific set of genes under the influence of developmental signals. MrpC is a member of the …

Molecular mechanisms of signaling in Myxococcus xanthus development

DJ Bretl, JR Kirby - Journal of molecular biology, 2016 - Elsevier
Myxococcus xanthus is an environmental bacterium that displays a complex life cycle that
includes motility, predation, multicellular fruiting body development, and sporulation. Given …

Behavior of peripheral rods and their role in the life cycle of Myxococcus xanthus

KA O'Connor, DR Zusman - Journal of bacteriology, 1991 - Am Soc Microbiol
Myxococcus xanthus is a gram-negative bacterium with a complex life cycle including a
developmental phase in which cells aggregate and sporulate in response to starvation. In …