SUMMARY The cocaine analog 23-carboxymethoxy-39-(4-fiuorophenyl)-tropane (CFT)
binds to platelet plasma membrane vesicles.[3H] CFT binding is blocked equally well by …

SUMMARY The iodinated cocaine analog 2/3-carbomethoxy-3fl-(4-[125l] iodophenyl)
tropane(j9-[125l} CIT) binds with high affinity to the platelet plasma membrane serotonin …

4a, R=(CH3) 2CH, X= CI b, R=(CH3) 2CH, X= 1 c, R=(CH3) 2CH, X= CH3 5a, R= C6H5l X=
CI b, R= C6K5, X= I c, R= C6H5i X= CH3 agents useful in the treatment of cocaine abuse …

Abstract Structure-activity relationships for cocaine and analog binding at the dopamine,
norepinephrine and serotonin transporters were determined. Cocaine inhibition of ligand …

Several 2/3-carboxylic acid ester and amide analogues of cocaine and of 3/3-(4'-substituted
phenyl) tropane-2/3-carboxylic acid were prepared. The binding affinities of these …

Four analogs and two homologs of cocaine, designed as potent cocaine antagonists, were
synthesized. The SN2 reaction between ecgonine methyl ester (1 3) or appropriately …

SEVERAL isopropyl and phenyl esters of 3 [beta]-(4-substituted phenyl) tropan-2 [beta]-
carboxylic acid analogs of cocaine are relatively more potent and selective than cocaine and …

Earlier work characterized the binding of the high-affinity cocaine analog 3 beta-(4-
125iodophenyl)-tropane-2-carboxylic acid methyl ester ([125I] RTI-55) to membranes …

The addictive and euphorogenic properties of cocaine are thought to result from inhibition of
the dopamine transporter (DAT). Recent evidence suggests that dopamine and cocaine bind …

The definition of the pharmacophore for the cocaine (la) binding site on the dopamine
transporter has been the subject of considerable scientific interest for the last few years. 1-9 …