The 8; 21 chromosome translocation in acute myeloid leukemia is always detectable by molecular analysis using AML1

N Maseki, H Miyoshi, K Shimizu, C Homma, M Ohki… - 1993 - ashpublications.org
The AML1 gene was rearranged in leukemic cells with t (8; 21)(q22; q22) or its variant,
complex t (8; V; 21) translocations from 33 acute myeloid leukemia (AML) patients. The …

4; 11 translocation-associated acute leukemia: A comprehensive analysis

M De Braekeleer, CC Lin - Cancer Genetics and Cytogenetics, 1986 - Elsevier
A girl with common acute lymphoblastic leukemia associated with t (4; 11)(q21; q23) is
presented. The physical examination revealed hepatosplenomegaly, and the hematologic …

Detection of AML1/ETO fusion transcript as a tool for diagnosing t (8; 21) positive acute myelogenous leukemia.

F Maruyama, SA Stass, EH Estey, A Cork, M Hirano… - Leukemia, 1994 - europepmc.org
The nonrandom chromosomal translocation t (8; 21)(q22; q22) can be found frequently in
acute myelogenous leukemia with maturation (AML-M2). The breakpoint of this translocation …

Hematological features and treatment outcome in acute myeloid leukemia with t (8; 21)

SK Ma, WY Au, YL Kwong, CK Lam… - Hematological …, 1997 - Wiley Online Library
We analyzed the hematological features and treatment outcome in 18 patients with t (8; 21)
acute myeloid leukemia (AML) diagnosed in Queen Mary Hospital, Hong Kong. They …

Persistence of the 8; 21 translocation in patients with acute myeloid leukemia type M2 in long-term remission

G Nucifora, RA Larson, JD Rowley - 1993 - ashpublications.org
The translocation between chromosomes 8 and 21, t (8; 21)(q22; q22), is the most frequent
abnormality in acute myeloid leukemia (AML) with French-American-British type M2 (FAB …

Fluorescence in situ hybridization analysis of masked (8; 21)(q22; q22) translocations

CJ Harrison, I Radford-Weiss, F Ross, K Rack… - Cancer genetics and …, 1999 - Elsevier
The translocation (8; 21)(q22; q22) is associated with acute myeloblastic leukemia (AML
M2). The accurate detection of this chromosomal rearrangement is vital due to its …

Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t (8; 21) acute myeloid leukemia

G Nucifora, DJ Birn, P Erickson, J Gao, MM LeBeau… - 1993 - ashpublications.org
Abstract The (8; 21)(q22; q22) translocation is a frequent karyotypic abnormality seen in
approximately 40% of patients with acute myeloid leukemia subtype M2 (AML-M2) and an …

AML with translocation t (8; 16)(p11; p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features

T Haferlach, A Kohlmann, HU Klein, C Ruckert… - Leukemia, 2009 - nature.com
Balanced chromosomal rearrangements define distinct entities in acute myeloid leukemia
(AML). Here, we present 13 AML cases with t (8; 16)(p11; p13) with observed low incidence …

Disease features in acute myeloid leukemia with t (8; 21)(q22; q22). Influence of age, secondary karyotype Abnormalities, CD19 status, and extramedullar leukemia on …

K Rege, GJ Swansbury, AA Atra, C Horton… - Leukemia & …, 2000 - Taylor & Francis
Over a period of 14 years, 50 patients (12 children and 38 adults) of whom 46 had acute
myeloid leukemia (AML) and 4 had myelodysplastic syndrome characterized by the t (8; …

A new trans, location, t (5; 21)(g13; q22) in acute myelogenousc leukemia

SK Gogineni, M da Costa, RS Verma - Cancer genetics and cytogenetics, 1996 - Elsevier
We report a case of acute myelogenous leukemia with a variant translocation involving
chromosomes 5 and 21 with breakpoints on 5813 and 21822 as revealed by various …