Aging causes functional decline and degeneration of neurons and is a major risk factor of
neurodegenerative diseases. To investigate the molecular mechanisms underlying neuronal …

The heterogeneity and multigenetic nature of nervous system aging make modeling of it a
formidable task in mammalian species. The powerful genetics, simple anatomy and short life …

Understanding cellular outcomes, such as neuronal remodeling, that are common to both
healthy and diseased aging brains is essential to the development of successful brain aging …

Aging is characterized by a progressive decline in multiple physiological functions (ie,
functional aging). As animals age, they exhibit a gradual loss in motor activity, but the …

PTL-1 is the sole homolog of the MAP2/MAP4/tau family in Caenorhabditis elegans.
Accumulation of tau is a pathological hallmark of neurodegenerative diseases such as …

Temperature is one of the primary environmental factors that affect aging, in which protein
phosphorylation is an important regulator. Currently, the understanding of phosphorylation …

In the aging brain, many of the alterations underlying cognitive and behavioral decline
remain opaque. Caenorhabditis elegans offers a powerful model for aging research, with a …

Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal
and molecular processes. Technological innovations now allow for parallel investigation of …

Aging of the nervous system underlies the behavioral and cognitive decline associated with
senescence. Understanding the molecular and cellular basis of neuronal aging will …

Numerous genetic targets and some individual pathways associated with aging have been
identified using the worm model. However, less is known about the genetic mechanisms of …