A lipidomic analysis of placenta in preeclampsia: evidence for lipid storage

SHJ Brown, SR Eather, DJ Freeman, BJ Meyer… - Plos one, 2016 - journals.plos.org
In preeclampsia, maternal insulin resistance leads to defective expansion of adipocytes,
enhanced adipocyte lipolysis, up-regulation of very low density lipoprotein synthesis …

[HTML][HTML] Increased placental phospholipid levels in pre-eclamptic pregnancies

X Huang, A Jain, M Baumann, M Körner… - International journal of …, 2013 - mdpi.com
Physiological pregnancy is associated with an increase in lipids from the first to the third
trimester. This is a highly regulated response to satisfy energy and membrane demands of …

Lipidomic assessment of plasma and placenta of women with early-onset preeclampsia

HA Korkes, N Sass, AF Moron, NOS Câmara… - PLoS …, 2014 - journals.plos.org
Introduction Adipose tissue is responsible for triggering chronic systemic inflammatory
response and these changes may be involved in the pathophysiology of preeclampsia …

The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia

B He, Y Liu, MR Maurya, P Benny, C Lassiter, H Li… - Journal of lipid …, 2021 - ASBMB
Preeclampsia is a pregnancy-specific syndrome characterized by hypertension and
proteinuria after 20 weeks of gestation. However, it is not well understood what lipids are …

Role of dyslipidemia in preeclampsia—A review of lipidomic analysis of blood, placenta, syncytiotrophoblast microvesicles and umbilical cord artery from women with …

D Wojcik-Baszko, K Charkiewicz… - Prostaglandins & Other …, 2018 - Elsevier
Preeclampsia is a complex disorder and the pathogenesis of it is still not fully understood.
The most commonly accepted theory of pathogenesis assumes that there occurs impaired …

Placental lipid metabolism in preeclampsia

AA Khaire, SR Thakar, GN Wagh… - Journal of …, 2021 - journals.lww.com
Objectives: The current study examines the placental and maternal lipid profile and
expression of genes involved in placental lipid metabolism in women with preeclampsia …

Maternal and fetal modulators of lipid metabolism correlate with the development of preeclampsia

JT Mural, E Muzykanskiy, RN Taylor - Metabolism, 1997 - Elsevier
The pregnancy syndrome preeclampsia is associated with placental dysfunction,
dyslipidemia, and endothelial cell activation, and is a major cause of maternal and fetal …

Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for …

MR Hentschke, CE Poli-de-Figueiredo… - Journal of Lipid …, 2013 - ASBMB
Atherosis of spiral arteries in uteroplacental beds from preeclamptic women resemble those
of atherosclerosis, characterized by increased plasma lipids and lipoproteins. We …

Lipid fingerprinting in women with early-onset preeclampsia: a first look

L De Oliveira, NOS Câmara, T Bonetti, EGL Turco… - Clinical …, 2012 - Elsevier
OBJECTIVES: The aim of this preliminary study was to characterize the plasma lipid profiling
of women with preeclampsia. DESIGN AND METHODS: Plasma samples of 8 pregnant …

Effects of obesity and gestational diabetes mellitus on placental phospholipids

O Uhl, H Demmelmair, MT Segura, J Florido… - Diabetes research and …, 2015 - Elsevier
Gestational diabetes mellitus (GDM) is associated with adverse effects in the offspring. The
composition of placental glycerophospholipids (GPL) is known to be altered in GDM and …