Experimental autoimmune encephalomyelitis (EAE) is a model of human multiple sclerosis
induced by autoreactive Th cells that mediate tissue inflammation and demyelination in the …

During the development of experimental autoimmune encephalomyelitis (EAE), the
proportion of pathogenic and myelin-specific cells within CNS-infiltrating cytokine-producing …

Background There is consensus that experimental autoimmune encephalomyelitis (EAE)
can be mediated by myelin specific T cells of Th1 as well as of Th17 phenotype, but the …

Experimental autoimmune encephalomyelitis (EAE) is a mouse model for multiple sclerosis,
where disease is mediated by autoantigen-specific T cells. Although there is evidence …

Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis
(EAE), are autoimmune demyelinating diseases of the central nervous system (CNS) …

The extent to which myelin-specific Th1 and Th17 cells contribute to the pathogenesis of
experimental autoimmune encephalomyelitis (EAE) is controversial. Combinations of …

It has recently been proposed that experimental autoimmune encephalomyelitis, once
considered the classical Th1 disease, is predominantly Th17 driven. In this study we show …

Multiple sclerosis (MS) is believed to be initiated by myelin-reactive CD4+ Th cells. IL-12–
polarized Th1 cells, IL-23–polarized Th17 cells, and Th17 cells that acquire Th1 …

IL-17–producing CD8+ T (Tc17) cells are detectible in multiple sclerosis (MS) lesions;
however, their contribution to the disease is unknown. To identify functions of Tc17 cells, we …

CNS-resident cells, in particular microglia and macrophages, are a source of inflammatory
cytokines during inflammation within the CNS. Expression of IL-23, a recently discovered …