Osteosarcoma is the most common primary bone cancer affecting children and adolescents
worldwide. Despite an incidence of three cases per million annually, it accounts for an …

Osteosarcoma, a bone cancer most commonly seen in adolescents and young adults, is
usually a high-grade malignancy characterized by a very high risk for the development of …

Osteosarcoma is the most common bone sarcoma, which mainly affects adolescents and
young adults. Although the combination of modern surgery and systemic chemotherapy has …

Osteosarcoma, a bone cancer usually seen in children and young adults, is generally a high-
grade malignancy presented by extreme metastases to the lungs. Osteosarcoma has a …

Despite numerous chemotherapy trials and the introduction of novel agents, survival in
localized osteosarcoma, which plateaued in the mid-1980s, has been recalcitrant to our best …

Examination of the survival rate of 5-year cohorts with primary osteosarcoma registered by
the Thames Cancer Registry between 1963 and 1982 and followed up to the end of 1984 …

Chemotherapy in osteosarcoma has had a major impact in attaining metastasis-free
survival, and the cure rates with the use of modern regimens range from 65% to 75 …

Abstract Background/Objective To analyze changes in recurrent/refractory osteosarcoma
phase II trials over time to inform future trials in this population with poor prognosis. Methods …

Systemic therapy has improved osteosarcoma event-free and overall survival, but 30–50%
of patients originally diagnosed will have progressive or recurrent disease, which is difficult …

Background A previous trial by the European Osteosarcoma Intergroup (EOI) suggested that
a short intensive chemotherapy regimen with doxorubicin and cisplatin might produce …