Multiple sclerosis (MS) is an autoimmune demyelinating neurodegenerative disease of the
central nervous system (CNS) due to injury of the myelin sheath by immune cells. The …

FGF2 is considered a key factor in the generation of oligodendrocytes (OLs) derived from
neural stem cells (NSCs) located within the subventricular zone (SVZ). Here, we have …

Fingolimod (FTY720) is a sphingosine 1‐phosphate (S1P) receptor analog, which has been
approved as an oral immunomodulator for treating relapsing–remitting multiple sclerosis …

ABSTRACT FGF1 is involved in multiple biological functions and exhibits the importance in
neuroprotective effects. Our previous studies indicated that, in human brain and retina, the …

Insulin-like growth factor-I (IGF-I), platelet-derived growth factor (PDGF), fibroblast growth
factor (FGF) and ciliary neurotrophic factor (CNTF) are multifunctional growth factors which …

Dramatic changes in morphology and myelin protein expression take place during the
differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes …

Fibroblast growth factor 2 (FGF-2) has multiple, pleiotropic effects on the nervous system that
include neurogenesis, neuroprotection and neuroplasticity. Thus, alteration in FGF-2 …

Background Lyme neuroborreliosis, caused by the bacterium Borrelia burgdorferi affects
both the central and peripheral nervous systems (CNS, PNS). The CNS manifestations …

Background The accumulation of activated microglia is a hallmark of various
neurodegenerative diseases. Microglia may have both protective and toxic effects on …

Fibroblast growth factor receptors (Fgfr) comprise a widely expressed family of
developmental regulators implicated in oligodendrocyte (OL) maturation of the CNS. Fgfr2 is …