siRNA therapy, challenges and underlying perspectives of dendrimer as delivery vector
R Kumar Tekade, R GS Maheshwari… - Current …, 2015 - ingentaconnect.com
siRNA technology presents a helpful means of gene silencing in mammalian cells.
Advancement in the field includes enhanced attentiveness in the characterization of target …
Advancement in the field includes enhanced attentiveness in the characterization of target …
Dendrimers as non-viral vectors for siRNA delivery
There is a tremendous interest in moving siRNA therapeutics into a clinical setting for the
treatment of various diseases. This in itself however depends largely on the availability of …
treatment of various diseases. This in itself however depends largely on the availability of …
Delivering siRNA with dendrimers: In vivo applications
V Leiro, S Duque Santos… - Current Gene Therapy, 2017 - ingentaconnect.com
Over the last decades, gene therapy has emerged as a pioneering therapeutic approach to
treat or prevent several diseases. Among the explored strategies, the short-term silencing of …
treat or prevent several diseases. Among the explored strategies, the short-term silencing of …
Surface engineered dendrimers in siRNA delivery and gene silencing
Background: Therapeutic efficacy of dreadful diseases like cancer, HIV (Human
Immunodeficiency Virus) can be enhanced by delivering molecules which regulate function …
Immunodeficiency Virus) can be enhanced by delivering molecules which regulate function …
Carbosilane dendrimers as carriers of siRNA
Despite the enormous possibilities of RNAi, there still exist many problems that need to be
addressed. Obstacles in delivery, target cell transfection, stability/degradation, transient …
addressed. Obstacles in delivery, target cell transfection, stability/degradation, transient …
Dendrimers as carriers for siRNA delivery and gene silencing: a review
J Wu, W Huang, Z He - The Scientific World Journal, 2013 - Wiley Online Library
RNA interference (RNAi) was first literaturally reported in 1998 and has become rapidly a
promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small …
promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small …
[HTML][HTML] Dendrimers for siRNA delivery
S Biswas, VP Torchilin - Pharmaceuticals, 2013 - mdpi.com
Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of
polymers has gained considerable attention for numerous biomedical applications, due …
polymers has gained considerable attention for numerous biomedical applications, due …
A combination of guanidyl and phenyl groups on a dendrimer enables efficient siRNA and DNA delivery
H Chang, J Zhang, H Wang, J Lv, Y Cheng - Biomacromolecules, 2017 - ACS Publications
Gene therapy has received considerable attention due to its great potential in the treatment
of various diseases; however, the design of efficient and biocompatible carriers for the …
of various diseases; however, the design of efficient and biocompatible carriers for the …
Targeted delivery of Dicer-substrate siRNAs using a dual targeting peptide decorated dendrimer delivery system
X Liu, C Liu, C Chen, M Bentobji, FA Cheillan… - … , Biology and Medicine, 2014 - Elsevier
Small interfering RNAs (siRNA) are emerging as novel therapeutic agents, providing
competent delivery systems that are available. Dendrimers, a special family of synthetic …
competent delivery systems that are available. Dendrimers, a special family of synthetic …
[HTML][HTML] Dendrimers show promise for siRNA and microRNA therapeutics
The lack of an appropriate intracellular delivery system for therapeutic nucleic acids (TNAs)
is a major problem in molecular biology, biotechnology, and medicine. A relatively new class …
is a major problem in molecular biology, biotechnology, and medicine. A relatively new class …