Ethnicity in pulmonary arterial hypertension: possibilities for novel phenotypes in the age of personalized medicine

SK Medrek, S Sahay - Chest, 2018 - Elsevier
In the past decade and a half, the introduction of new therapeutic agents has revolutionized
the management of pulmonary arterial hypertension (PAH). These new treatment options …

Genetic admixture and survival in diverse populations with pulmonary arterial hypertension

JH Karnes, HW Wiener, TH Schwantes-An… - American journal of …, 2020 - atsjournals.org
Rationale: Limited information is available on racial/ethnic differences in pulmonary arterial
hypertension (PAH). Objectives: Determine effects of race/ethnicity and ancestry on mortality …

Effect of age on phenotype and outcomes in pulmonary arterial hypertension trials

JA Rose, JM Cleveland, Y Rao, OA Minai, AR Tonelli - Chest, 2016 - Elsevier
Background In recent years, the population of patients with pulmonary arterial hypertension
(PAH) has changed dramatically, including more advanced age at diagnosis. We …

Racial and ethnic differences in pulmonary arterial hypertension

N Al-Naamani, JK Paulus, KE Roberts… - Pulmonary …, 2017 - journals.sagepub.com
This study explores the racial and ethnic differences in presentation, severity, and treatment
of patients with pulmonary arterial hypertension (PAH) in a large multicenter registry. African …

Impact of race on survival in pulmonary arterial hypertension: results from the REVEAL registry

S Medrek, S Sahay, C Zhao, M Selej, A Frost - The Journal of Heart and …, 2020 - Elsevier
BACKGROUND Prior research has suggested that the prevalence and outcomes of
pulmonary arterial hypertension (PAH) may vary by race or ethnicity. However, these studies …

Pulmonary Arterial hypertension in the elderly: peculiar features and challenges for a proper phenotyping approach

R Scagliola, C Brunelli, M Balbi - Journal of Cardiovascular Development …, 2023 - mdpi.com
(1) Introduction. Although pulmonary arterial hypertension (PAH) usually affects young
people with a low cardiovascular risk profile, progressive epidemiologic changes have been …

Genomics of pulmonary arterial hypertension: implications for therapy

MW Geraci, TM Bull, RM Tuder - Heart failure clinics, 2010 - heartfailure.theclinics.com
The first descriptions of pulmonary arterial hypertension (PAH) have fascinated clinicians
and scientists since these brief initial descriptions. Despite significant advances in the …

A paradigm shift is needed in the field of pulmonary arterial hypertension for its entrance into the precision medicine era

V Gurtu, ED Michelakis - Circulation research, 2016 - Am Heart Assoc
But the diverse molecular pathways that lead to the same endresult are lost by WHO
classifications, which are driven by a diagnosis of exclusion, using common tests to prove …

Genetics and genomics of pulmonary arterial hypertension

NW Morrell, MA Aldred, WK Chung… - European …, 2019 - Eur Respiratory Soc
Since 2000 there have been major advances in our understanding of the genetic and
genomics of pulmonary arterial hypertension (PAH), although there remains much to …

Genetic counselling and testing in pulmonary arterial hypertension: a consensus statement on behalf of the International Consortium for Genetic Studies in PAH

CA Eichstaedt, C Belge, WK Chung… - European …, 2023 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a rare disease that can be caused by (likely)
pathogenic germline genomic variants. In addition to the most prevalent disease gene …