In vitro and in vivo tumor models for the evaluation of anticancer nanoparticles
Multiple studies about tumor biology have revealed the determinant role of the tumor
microenvironment in cancer progression, resulting from the dynamic interactions between …
microenvironment in cancer progression, resulting from the dynamic interactions between …
Tumor in 3D: in vitro complex cellular models to improve nanodrugs cancer therapy
Nanodrugs represent novel solutions to reshuffle repurposed drugs for cancer therapy. They
might offer different therapeutic options by combining targeted drug delivery and imaging in …
might offer different therapeutic options by combining targeted drug delivery and imaging in …
Designing an In Vivo Efficacy Study of Nanomedicines for Preclinical Tumor Growth Inhibition
PP Adiseshaiah, ST Stern - … of Nanoparticles Intended for Drug Delivery, 2018 - Springer
Novel nanoformulated chemotherapeutics and diagnostics require demonstration of efficacy
and safety in appropriate animal models prior to conducting early-phase clinical trials. In …
and safety in appropriate animal models prior to conducting early-phase clinical trials. In …
Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening
M Millard, I Yakavets, V Zorin… - International journal …, 2017 - Taylor & Francis
The increasing number of publications on the subject shows that nanomedicine is an
attractive field for investigations aiming to considerably improve anticancer chemotherapy …
attractive field for investigations aiming to considerably improve anticancer chemotherapy …
Best practices for preclinical in vivo testing of cancer nanomedicines
Significant advances have been made in the development of nanoparticles for cancer
treatment in recent years. Despite promising results in preclinical animal models, cancer …
treatment in recent years. Despite promising results in preclinical animal models, cancer …
Tumor spheroid-based microtumor models for preclinical evaluation of anticancer nanomedicines
Abstract Background Cancer nanomedicines (NMs) have emerged as potential anticancer
therapeutics with advantages of tumor-targeting drug delivery for improved efficacy against …
therapeutics with advantages of tumor-targeting drug delivery for improved efficacy against …
From 2D to 3D cancer cell models—the enigmas of drug delivery research
Over the past decades, research has made impressive breakthroughs towards drug delivery
systems, resulting in a wide range of multifunctional engineered nanoparticles with …
systems, resulting in a wide range of multifunctional engineered nanoparticles with …
Three-dimensional culture models: emerging platforms for screening the antitumoral efficacy of nanomedicines
LB Tofani, MT Luiz, JA Paes Dutra, JP Abriata… - …, 2023 - Taylor & Francis
Nanomedicines have been investigated for delivering drugs to tumors due to their ability to
accumulate in the tumor tissues. 2D in vitro cell culture has been used to investigate the …
accumulate in the tumor tissues. 2D in vitro cell culture has been used to investigate the …
[HTML][HTML] Tumor microenvironment and nanotherapeutics
M Upreti, A Jyoti, P Sethi - Translational cancer research, 2013 - ncbi.nlm.nih.gov
Recent studies delineate a predominant role for the tumor microenvironment in tumor growth
and progression. Improved knowledge of cancer biology and investigation of the complex …
and progression. Improved knowledge of cancer biology and investigation of the complex …
Modeling of nanotherapy response as a function of the tumor microenvironment: focus on liver metastasis
The tumor microenvironment (TME) presents a challenging barrier for effective nanotherapy-
mediated drug delivery to solid tumors. In particular for tumors less vascularized than the …
mediated drug delivery to solid tumors. In particular for tumors less vascularized than the …