Associations of Lifestyle and Genetic Risks with Obesity and Related Chronic Diseases in the UK Biobank: A Prospective Cohort Study

Y Zhang, Y Li, R Peila, T Wang, X Xue… - The American Journal of …, 2024 - Elsevier
Background Interplay between lifestyle risk scores (LRSs) and genetic risk scores (GRSs) on
obesity and related chronic diseases are underinvestigated and necessary for …

Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants

CA Celis-Morales, DM Lyall, SR Gray, L Steell… - International journal of …, 2017 - nature.com
Background: Obesity is a multifactorial condition influenced by both genetics and lifestyle.
The aim of this study was to investigate whether the association between a validated genetic …

Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities

MS Kim, I Shim, AC Fahed, R Do, WY Park… - Cell Metabolism, 2024 - cell.com
The extent to which modifiable lifestyle factors offset the determined genetic risk of obesity
and obesity-related morbidities remains unknown. We explored how the interaction between …

Effects of gene–lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis

S Nakamura, X Fang, Y Saito, H Narimatsu, A Ota… - PloS one, 2023 - journals.plos.org
Background The relationship between lifestyle and obesity is a major focus of research.
Personalized nutrition, which utilizes evidence from nutrigenomics, such as gene …

How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? A 4-way decomposition analysis using UK Biobank

M Zhang, J Ward, RJ Strawbridge, C Celis-Morales… - BMC medicine, 2024 - Springer
Background Obesity and central obesity are multifactorial conditions with genetic and non-
genetic (lifestyle and environmental) contributions. There is incomplete understanding of …

Healthful plant-based dietary patterns, genetic risk of obesity, and cardiovascular risk in the UK biobank study

Y Heianza, T Zhou, D Sun, FB Hu, L Qi - Clinical Nutrition, 2021 - Elsevier
Background & aims People with a higher genetic risk for obesity are more likely to develop
cardiovascular disease (CVD), and healthy plant-based dietary patterns may be associated …

Deciphering the Interplay between Genetic Risk Scores and Lifestyle Factors on Individual Obesity Predisposition

D Chermon, R Birk - Nutrients, 2024 - mdpi.com
Obesity's variability is significantly influenced by the interplay between genetic and
environmental factors. We aimed to integrate the combined impact of genetic risk score …

Genetic susceptibility to obesity and diet intakes: association and interaction analyses in the Malmö Diet and Cancer Study

G Rukh, E Sonestedt, O Melander, B Hedblad, E Wirfält… - Genes & nutrition, 2013 - Springer
Gene–environment interactions need to be studied to better understand the obesity. We
aimed at determining whether genetic susceptibility to obesity associates with diet intake …

Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank

HS Dashti, N Miranda, BE Cade, T Huang, S Redline… - BMC medicine, 2022 - Springer
Background Genetic and lifestyle factors have considerable effects on obesity and related
diseases, yet their effects in a clinical cohort are unknown. This study in a patient biobank …

Can healthy lifestyle offset the genetic predisposition to obesity to prevent coronary heart disease?

Y Zhang, Q Qi - The American Journal of Clinical Nutrition, 2023 - ajcn.nutrition.org
Coronary heart disease (CHD) is the leading cause of death and a major contributor to
disease burden worldwide [1]. Abdominal obesity is a well-established risk factor for CHD …