Associations of Lifestyle and Genetic Risks with Obesity and Related Chronic Diseases in the UK Biobank: A Prospective Cohort Study
Y Zhang, Y Li, R Peila, T Wang, X Xue… - The American Journal of …, 2024 - Elsevier
Background Interplay between lifestyle risk scores (LRSs) and genetic risk scores (GRSs) on
obesity and related chronic diseases are underinvestigated and necessary for …
obesity and related chronic diseases are underinvestigated and necessary for …
Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants
Background: Obesity is a multifactorial condition influenced by both genetics and lifestyle.
The aim of this study was to investigate whether the association between a validated genetic …
The aim of this study was to investigate whether the association between a validated genetic …
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities
The extent to which modifiable lifestyle factors offset the determined genetic risk of obesity
and obesity-related morbidities remains unknown. We explored how the interaction between …
and obesity-related morbidities remains unknown. We explored how the interaction between …
Effects of gene–lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis
S Nakamura, X Fang, Y Saito, H Narimatsu, A Ota… - PloS one, 2023 - journals.plos.org
Background The relationship between lifestyle and obesity is a major focus of research.
Personalized nutrition, which utilizes evidence from nutrigenomics, such as gene …
Personalized nutrition, which utilizes evidence from nutrigenomics, such as gene …
How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? A 4-way decomposition analysis using UK Biobank
Background Obesity and central obesity are multifactorial conditions with genetic and non-
genetic (lifestyle and environmental) contributions. There is incomplete understanding of …
genetic (lifestyle and environmental) contributions. There is incomplete understanding of …
Healthful plant-based dietary patterns, genetic risk of obesity, and cardiovascular risk in the UK biobank study
Background & aims People with a higher genetic risk for obesity are more likely to develop
cardiovascular disease (CVD), and healthy plant-based dietary patterns may be associated …
cardiovascular disease (CVD), and healthy plant-based dietary patterns may be associated …
Deciphering the Interplay between Genetic Risk Scores and Lifestyle Factors on Individual Obesity Predisposition
D Chermon, R Birk - Nutrients, 2024 - mdpi.com
Obesity's variability is significantly influenced by the interplay between genetic and
environmental factors. We aimed to integrate the combined impact of genetic risk score …
environmental factors. We aimed to integrate the combined impact of genetic risk score …
Genetic susceptibility to obesity and diet intakes: association and interaction analyses in the Malmö Diet and Cancer Study
G Rukh, E Sonestedt, O Melander, B Hedblad, E Wirfält… - Genes & nutrition, 2013 - Springer
Gene–environment interactions need to be studied to better understand the obesity. We
aimed at determining whether genetic susceptibility to obesity associates with diet intake …
aimed at determining whether genetic susceptibility to obesity associates with diet intake …
Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank
Background Genetic and lifestyle factors have considerable effects on obesity and related
diseases, yet their effects in a clinical cohort are unknown. This study in a patient biobank …
diseases, yet their effects in a clinical cohort are unknown. This study in a patient biobank …
Can healthy lifestyle offset the genetic predisposition to obesity to prevent coronary heart disease?
Coronary heart disease (CHD) is the leading cause of death and a major contributor to
disease burden worldwide [1]. Abdominal obesity is a well-established risk factor for CHD …
disease burden worldwide [1]. Abdominal obesity is a well-established risk factor for CHD …
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