Introduction• Pathological markers of hypoxia‐Necrosis‐Hypoxia inducible factor (HIF)
targets‐HIF‐1 versus HIF‐2‐Early versus late stage cancer‐Intratumour heterogeneity …

Hypoxia is a feature of most solid tumours and is associated with a poor prognosis. The
hypoxic environment can reduce the efficacy of radiotherapy and some chemotherapeutics …

Tumor hypoxia is related to tumor progression and therapy resistance, which leads to poor
patient outcome. It has been suggested that measuring the hypoxic status of a tumor helps to …

Hypoxia is a common feature of solid tumours affecting their biology and response to
therapy. One of the main transcription factors activated by hypoxia is hypoxia-inducible …

Tumour hypoxia is a major contributor to resistance to anticancer therapies. Given that the
results of hypoxia-targeted therapy trials have been disappointing, a more personalized …

The pivotal role of hypoxia within the pathophysiological framework of solid malignant
tumors is now considered to be indisputable. The fact that hypoxia can cause resistance to …

Background: There is a need to develop robust and clinically applicable gene expression
signatures. Hypoxia is a key factor promoting solid tumour progression and resistance to …

Abstract Learning Objectives After completing this course, the reader will be able to:
Describe hypoxia-induced mechanisms for cell survival. Discuss hypoxia-induced gene …

Metastases formation is a major factor in disease progression and accounts for the majority
of cancer deaths. The molecular mechanisms controlling invasion, dissemination to blood or …

Hypoxic environments occur normally at high altitude, or in underground burrows and in
deep sea habitats. They also occur pathologically in human ischemia and in hypoxic solid …