Abstract Development of efficient molecular medicines, including gene therapeutics, RNA
therapeutics, and DNA vaccines, depends on efficient means of transfer of DNA or RNA into …

Due to the growing concerns over the toxicity and immunogenicity of viral DNA delivery
systems, DNA delivery via non-viral routes has become more desirable and advantageous …

Diverse polycationic polymers have been used as nonviral transfection agents. Here we
report the ability of colloidal silica particles with covalently attached cationic surface …

We have known for a while that silica is a promising candidate gene delivery vector. New in
vivo data from Dhruba Bharali and co-workers raise the hopes a notch for such approaches …

Silica-based nanoparticles are promising carriers for gene delivery applications. To gain
insights into the effect of particle size on gene transfection efficiency, amine-modified …

The transport of nucleic acid-based reagents is predicated upon developing structurally
stable delivery systems that can preferentially bind and protect DNA and RNA, and release …

COMMENTARY http://biotech. nature. com• AUGUST 2002• VOLUME 20• nature
biotechnology effort are advances in the materials used to assemble the DNA particles, such …

Advances in gene therapy have been foreshadowing its potential for the treatment of a vast
range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and …

Development of reliable vectors is a major challenge in gene therapy. Previous gene
transfer methods using non-viral vectors, such as liposomes or nanoparticles, have resulted …

The potential of cationic SiO2 nanoparticles was investigated for in vivo gene transfer in this
study. Cationic SiO2 nanoparticles with surface modification were generated using amino …