Introduction Controlling hypertension by angiotensin converting enzyme inhibitors (ACEI) or
angiotensin receptor blockers (ARB), mechanisms that inhibit later pathway steps in the …

We tested the hypothesis that the renin inhibitor aliskiren ameliorates organ damage in rats
transgenic for human renin and angiotensinogen genes (double transgenic rat [dTGR]). Six …

The blood pressure–independent effects of angiotensin II (Ang II) were examined in double
transgenic rats (dTGR) harboring human renin and human angiotensinogen genes, in which …

We studied the effects of extremely low-dose human renin inhibition (aliskiren) with low
angiotensin II receptor blockade (losartan) in a novel double-transgenic rat model …

Introduction: The hypertensive double-transgenic (dTG) rat strain, expressing human renin
and angiotensinogen, develops severe hypertension and organ damage and 50% of …

The renin-angiotensin system (RAS) plays a central role in the pathogenesis of proteinuric
renal diseases. dTGR rapidly develop hypertension (HT) and cardio-renal damage due to …

Several cardiac and renal diseases are attributed to a dysregulation of the renin-angiotensin
system. Renin, the rate-limiting enzyme of the renin-angiotensin system, has 2 isoforms. The …

Blockade of the renin-angiotensin system (RAS) with angiotensin I-converting enzyme
(ACE) inhibitors, angiotensin II type 1 (AT1) receptor (AT1R) blockers (ARB), or a …

Materials and Methods Animals and Administered Drugs THMs were divided in three
groups: a group treated with an ACEI (lisinopril)(20 mg/kg/d), a group treated with …

Aims Chronic endothelin receptor A (ET A) blockade lowered blood pressure (BP) by
decreasing angiotensin-dependent vasoconstriction and attenuating calcium influx. We …