Thyroid carcinoma consists a group of phenotypically heterogeneous cancers. Recent
advances in biological technologies have been advancing the delineation of genetic …

Biologic and Clinical Perspectives on Thyroid Cancer | New England Journal of Medicine Skip to
main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Background: Very little was known about the molecular pathogenesis of thyroid cancer until
the late 1980s. As part of the Centennial celebration of the American Thyroid Association …

Thyroid cancer derived from follicular cells (TCDFC) comprises well-differentiated (papillary
and follicular) carcinoma, poorly differentiated carcinoma, and anaplastic carcinoma …

Thyroid cancer is the most common malignancy of the endocrine system, and its incidence
has been steadily increasing. Advances in sequencing have allowed analysis of the entire …

Tumours can arise from thyroid follicular cells if they acquire driver mutations that
constitutively activate the MAPK signalling pathway. In addition, a limited set of additional …

Thyroid cancer is a common endocrine malignancy. There has been exciting progress in
understanding its molecular pathogenesis in recent years, as best exemplified by the …

There are 5 main histological types of thyroid cancers (TCs): papillary, follicular (also known
as differentiated), poorly differentiated, anaplastic (the most aggressive form), and medullary …

Differentiated thyroid cancers (DTCs) are primarily initiated by mutations that activate the
MAPK signaling cascade, typically at BRAF or RAS oncoproteins. DTCs can evolve to more …

The genomic landscape of thyroid cancers that are derived from follicular cells has been
substantially elucidated through the coordinated application of high-throughput genomic …