Within the last 15 years, multiple new signal transduction pathways within cells have been
discovered. Many of these pathways belong to what is now termed 'the mitogen-activated …

Ionizing radiation, like a variety of other cellular stress factors, can activate or down-regulate
multiple signaling pathways, leading to either increased cell death or increased cell …

The p38 group of kinases belongs to the mitogen-activated protein (MAP) kinase
superfamily with structural and functional characteristics distinguishable from those of the …

An increasing body of evidence suggests that mitogen-induced activation of the RAF/ERK
signaling pathway is functionally separate from the stress-induced activation of the …

Abstract Dent, P., Yacoub, A., Contessa, J., Caron, R., Amorino, G., Valerie, K., Hagan, MP,
Grant, S. and Schmidt-Ullrich, R. Stress and Radiation-Induced Activation of Multiple …

The molecular mechanism (s) by which tumor cells survive after exposure to ionizing
radiation are not fully understood. Exposure of A431 cells to low doses of radiation (1 Gy) …

Ionizing radiation, like a variety of other cellular stress factors, initiates apoptosis, or
programmed cell death, in many cell systems. This mode of radiation-induced cell kill should …

Exposure of MDA-MB-231 human mammary carcinoma cells to an ionizing radiation dose of
2 Gy results in immediate activation and Tyr phosphorylation of the epidermal growth factor …

Background: Stimuli that stress cells, including inflammatory cytokines, ultra-violet
irradiation, DNA-damaging chemotherapeutic drugs and heat shock, stimulate a recently …

Mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs including
embryogenesis, proliferation, differentiation and apoptosis based on cues derived from the …