Mitogen-activated/extracellular response kinase kinase (MEK) kinase (MEKK) is a serine-
threonine kinase that regulates sequential protein phosphorylation pathways, leading to the …

c-Jun N-terminal kinases (JNKs) participate in cellular responses to mitogenic stimuli,
environmental stresses, and apoptotic agents. The mechanisms by which JNK integrates …

Abstract Schmidt-Ullrich, RK, Dent, P., Grant S., Mikkelsen, RB and Valerie, K. Signal
Transduction and Cellular Radiation Responses. Exposure of cells to ionizing radiation …

Abstract Hagan, M., Wang, L., Hanley, JR, Park, JS and Dent, P. Ionizing Radiation-Induced
Mitogen-Activated Protein (MAP) Kinase Activation in DU145 Prostate Carcinoma Cells …

Sequential activation of protein kinases within the mitogen-activated protein kinase (MAPK)
cascades is a common mechanism of signal transduction in many cellular processes. Four …

The mitogen-activated protein kinase (MAPK) pathways are known to be involved in various
processes of growth, differentiation and cell death. In spite of their ubiquitous presence and …

The mitogen-activated protein kinase (MAPK) family of kinases connects extracellular stimuli
with diverse cellular responses ranging from activation or suppression of gene expression to …

Cells are continuously exposed to a variety of environmental stresses and have to decide 'to
be or not to be'depending on the types and strength of stress. Among the many signaling …

MAP kinases are signaling intermediaries that allow eukaryotic cells to interpret and
respond to many different stimuli. Three major MAP kinase pathways have been identified …

Ultraviolet (UV) irradiation stimulates stress-activated protein kinase/c-Jun N-terminal kinase
(SAPK/JNK), which is a member of the mitogen-activated protein kinase (MAPK) superfamily …