Mammalian cells respond to extracellular stimuli by activating signaling cascades that are
mediated by members of the MAP kinase family. MAP kinases act by phosphorylating …

The mammalian family of mitogen-activated protein kinases (MAPKs) includes extracellular
signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase (JNK), with each MAPK …

Abstract p38 mitogen-activated protein kinases (p38 MAPKs) are a group of serine/threonine
protein kinases that together with ERK (extracellular signal-regulated kinases) and JNK (c …

In this study, we investigated the mechanism by which UVB irradiation activates Akt (also
known as protein kinase B (PKB)) in mouse epidermal JB6 cells. Treatment with a …

Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members function in a cell context-specific and cell type-specific manner to integrate signals …

Ionizing or ultraviolet radiation-induced cellular survival signaling pathways induce
development of cancer and insensitivity of tumor cells to radiation therapy. Accumulating …

The ERK, p38MAPK, JNK mitogen-activated protein kinases (MAPKs) are intracellular
signaling pathways that play a pivotal role in many essential cellular processes such as …

Relevance of mitogen-activated protein kinases ERK, JNK, and p38 in the regulation of
myeloid differentiation. The MAPKs are a family of serine/threonine kinases that play an …

UV irradiation induces apoptosis in U937 human leukemic cells that is accompanied by the
activation of both the stress-activated protein kinase (SAPK) and p38 mitogen-activated …

Mitogen‐activated protein kinases (MAPKs) are serine‐threonine protein kinases that play
the major role in signal transduction from the cell surface to the nucleus. MAPKs, which …