Objective: To investigate haemorheological changes in patients undergoing coronary artery
bypass grafting and to determine whether the protective effect on haemorheology of high …

BACKGROUND The protease inhibitor aprotinin reduces blood loss and homologous blood
usage after a cardiac operation. The aim of the present study was to investigate the effect of …

Background: Previous studies showed that high-dose aprotinin reduces postoperative
bleeding in heart surgery and that blood cell rheologic parameters correlate to postoperative …

Propofol has previously been found to decrease hematocrit values. Because hematocrit is
an important determinant of blood viscosity, lower hematocrits may cause a decrease in …

Remarkable improvement in hemostasis after cardiopulmonary bypass has been achieved
by treatment with the proteinase inhibitor aprotinin, but the mechanism is still unclear. The …

Background: Aprotinin is a potent, nonspecific broad serine protease inhibitor. It's inhibitory
effects on intrinsic pathway of coagulation cascade can augment anticoagulation by heparin …

Prophylactic aprotinin therapy has become a popular method to reduce bleeding associated
with cardiac operations. Today essentially two dose regimens are used, a high-dose …

Background: Aprotinin interferes with heparin binding to platelets and decreases blood loss
during cardiopulmonary bypass (CPB). Heparin abolishes platelet force during CPB, and the …

Perioperative hemorrhage and thrombosis are serious complications associated with major
vascular surgery. We hypothesized that thoracic aortic occlusion-reperfusion in rabbits …

Aprotinin reduces blood loss following cardiopulmonary bypass operations (CPB) by the
prevention of hyperfibrinolysis. Its influence on circulating platelets is uncertain. In this …