Purpose The purpose of this study is to investigate the effect of two of the most important
functional CYP1A2 variations− 3860G> A and− 163C> A on carbamazepine …

Carbamazepine exhibits significant inter-individual variability in its efficacy and safety, which
leads to unpredictable therapy outcomes for the majority of patients. Although its complex …

Background The genetically polymorphic cytochrome P450 enzymes are involved in the
metabolism and elimination of a number of widely used drugs. CYP3A5 exhibits remarkable …

Although carbamazepine is one of the oldest anticonvulsant drugs, it is still heavily utilized
for treatment of epilepsy in children. The aim of this article was to review the current …

Purpose: To determine the effects of CYP3A5 polymorphisms on carbamazepine (CBZ)
pharmacokinetic parameters when CBZ is used either as monotherapy or co-administered …

Objective This study aims to investigate whether CYP3A5 polymorphisms affect steady-state
carbamazepine (CBZ) concentrations and therapeutic effects of CBZ monotherapy in …

Abstract Background and Objective: Carbamazepine (CBZ) is metabolized mainly by the
CYP3A family of enzymes, which includes CYP3A4 and CYP3A5. Several studies have …

AIM: The aim of the study was to compare the dose-adjusted plasma levels of
carbamazepine (CBZ) among expressers and nonexpressers of cytochrome P450 3A5 …

The authors describe a case of a 37-year-old Malay lady with an unusually slow
carbamazepine clearance, which may be related to genetic polymorphisms of drug …

Objective: To investigate the association between the CYP3A5 genetic polymorphism and
the serum concentrations of carbamazepine (CBZ), to provide guidance for individualized …