Bone remodeling is the continuous turnover of bone matrix and mineral by bone resorption
(activity of osteoclasts) and formation (activity of osteoblasts) in the adult skeleton. The …

Skeletal tissue is a reservoir of calcium that is important for proper muscle and nerve
function, and houses the marrow that supports the hematopoietic and mesenchymal stem …

While it has been long appreciated that biomechanical forces are involved in bone
remodeling and repair, the actual mechanism by which a physical force is translated to the …

Several in vivo and in vitro studies with different loading regimens showed that mechanical
stimuli have an influence on proliferation and differentiation of bone cells. Prerequisite for …

Bone tissue has the capacity to adapt to its functional environment such that its morphology
is “optimized” for the mechanical demand. The adaptive nature of the skeleton poses an …

The skeleton's primary mechanical function is to provide rigid levers for muscles to act
against as they hold the body upright in defiance of gravity. Many bones are exposed to …

The conceptual model of the mechanostat proposed by Harold Frost in 1983 is among the
most significant contributions to musculoskeletal research today. This model states that bone …

Mechanical force plays an important role in the regulation of bone remodelling in intact bone
and bone repair. In vitro, bone cells demonstrate a high responsiveness to mechanical …

An impressive range of tissues and cells are regulated by mechanical loading, and this
regulation is central to disease processes such as osteoporosis, atherosclerosis, and …

Bone demonstrates a remarkable ability to renew itself, adapt its architecture, and repair
fractures to maintain strength throughout life. Mechanobiology, the study of how external …