Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of
glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell …

The mood disorders major depressive disorder and bipolar disorder are prevalent, are
inadequately treated, and little is known about their etiologies. A better understanding of the …

Background Since the discovery of antidepressants, new treatments have emerged with
fewer side effects but no greater efficacy. Glycogen synthase kinase 3 β (GSK-3β), a kinase …

Glycogen synthase kinase-3 (GSK3) has recently been linked to mood disorders and
schizophrenia, and the neurotransmitter systems and therapeutic treatments associated with …

Abnormally active glycogen synthase kinase‐3 (GSK3) contributes to pathological
processes in multiple psychiatric and neurological disorders. Modeled in mice, this includes …

Background: Bipolar disorder (BD) is a debilitating mental ailment characterized by recurrent
episodes of mania and depression. Primary mood-stabilizing drugs like lithium and …

BACKGROUND: Glycogen synthase kinase-3 (GSK-3) has been linked to prodepressant-
like effects in rodents. However, the roles of GSK-3β and the hippocampal dentate gyrus in …

Little is known regarding the mechanisms underlying the complex etiology of mood
disorders, represented mainly by major depressive disorder and bipolar disorder. The 1996 …

Abstract Glycogen synthase kinase 3 (GSK3) has been linked to the mechanisms of stress,
mood regulation, and the effects of antidepressants. The functions of the GSK3β isoform …

Objective Glycogen synthase kinase-3β (GSK-3β) has become recognized as a broadly
influential enzyme affecting diverse range of biological functions, including gene expression …