[HTML][HTML] Combination therapy of mesenchymal stromal cells and interleukin-4 attenuates rheumatoid arthritis in a collagen-induced murine model

SM Haikal, NF Abdeltawab, LA Rashed, TI Abd El-Galil… - Cells, 2019 - mdpi.com
Rheumatoid arthritis (RA) is a disease of the joints that causes decreased quality of life.
Mesenchymal stromal cells (MSCs) have immunosuppressive properties, with possible use …

[HTML][HTML] Not single but periodic injections of synovial mesenchymal stem cells maintain viable cells in knees and inhibit osteoarthritis progression in rats

N Ozeki, T Muneta, H Koga, Y Nakagawa… - Osteoarthritis and …, 2016 - Elsevier
Objective We investigated the effects of single or repetitive intra-articular injections of
synovial mesenchymal stem cells (MSCs) on a rat osteoarthritis (OA) model, and elucidated …

The Effects of Mesenchymal Stem Cells on the Gene Expression of TGF-beta and IFN-gamma in Patients with Rheumatoid Arthritis

MR Khorashad, M Ghoryani, AG Shabgah… - Iranian Journal of …, 2023 - ijaai.tums.ac.ir
The therapeutic and immunomodulatory potential of mesenchymal stem cells (MSCs) in
rheumatoid arthritis (RA) has attracted considerable scientific attention in recent decades …

Human adipose-derived stem cells upregulate IGF-1 and alleviate osteoarthritis in a two-stage rabbit osteoarthritis model

J Wang, S Su, C Dong, Q Fan, J Sun… - Current Stem Cell …, 2024 - benthamdirect.com
Objective: In recent times, it has been recognized that mesenchymal stem cells (MSCs)
possess the capability to address osteoarthritis (OA). The objective of this research was to …

[HTML][HTML] Intra-articular injection of human synovium-derived mesenchymal stem cells in beagles with surgery-induced osteoarthritis

YS Kim, YI Kim, YG Koh - The Knee, 2021 - Elsevier
Background Recently, cell-based tissue engineering approaches using mesenchymal stem
cells (MSCs) have been used to treat osteoarthritis (OA). However, the efficacy of human …

Clinical-grade human embryonic stem cell-derived mesenchymal stromal cells ameliorate the progression of osteoarthritis in a rat model

D Xing, K Wang, J Wu, Y Zhao, W Liu, JJ Li, T Gao… - Molecules, 2021 - mdpi.com
Mesenchymalstem cell (MSC)-based therapy is being increasingly explored in preclinical
and clinical studies as a regenerative method for treating osteoarthritis (OA). However, the …

Low-dose xenogeneic mesenchymal stem cells target canine osteoarthritis through systemic immunomodulation and homing

C Beerts, SY Broeckx, E Depuydt, L Tack… - Arthritis Research & …, 2023 - Springer
Background As current therapies for canine osteoarthritis (OA) provide mainly symptomatic
improvement and fail to address the complex pathology of the disease, mesenchymal stem …

Immunoregulatory paracrine effect of mesenchymal stem cells and mechanism in the treatment of osteoarthritis

X Zhang, T Liu, C Ran, W Wang, F Piao… - Frontiers in Cell and …, 2024 - frontiersin.org
Osteoarthritis (OA) is a degenerative joint disease caused by chronic inflammation that
damages articular cartilage. At present, the treatment of OA includes drug therapy to relieve …

Understanding the effects of mesenchymal stromal cell therapy for treating osteoarthritis using an in vitro co-culture model

V Shang, J Li, CB Little, JJ Li - bioRxiv, 2022 - biorxiv.org
Osteoarthritis (OA) is a leading cause of chronic pain and disability, for which there is no
cure. Mesenchymal stromal cells (MSCs) have been used in clinical trials for treating OA due …

Effect of autologous bone marrow derived mesenchymal stem cells in treatment of rheumatoid arthritis

YI Elbasha, NM Mesbah, AR Abdel-Hamed… - Transplant …, 2023 - Elsevier
Introduction Chronic inflammation causes articular bone and cartilage degeneration in
people with rheumatoid arthritis (RA). Despite recent advancements in the management of …