[HTML][HTML] Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives
CR Harrell, BS Markovic, C Fellabaum… - Biomedicine & …, 2019 - Elsevier
Osteoarthritis (OA) is a chronic, prevalent, debilitating joint disease characterized by
progressive cartilage degradation, subchondral bone remodeling, bone marrow lesions …
progressive cartilage degradation, subchondral bone remodeling, bone marrow lesions …
Adipose‐Derived Mesenchymal Stem Cells Exert Antiinflammatory Effects on Chondrocytes and Synoviocytes From Osteoarthritis Patients Through Prostaglandin E2
C Manferdini, M Maumus, E Gabusi… - Arthritis & …, 2013 - Wiley Online Library
Objective To examine the effect of different sources of Good Manufacturing Practice clinical
grade adipose‐derived mesenchymal stem cells (AD‐MSCs) on inflammatory factors in …
grade adipose‐derived mesenchymal stem cells (AD‐MSCs) on inflammatory factors in …
Metformin augments anti-inflammatory and chondroprotective properties of mesenchymal stem cells in experimental osteoarthritis
MJ Park, SJ Moon, JA Baek, EJ Lee… - The Journal of …, 2019 - journals.aai.org
Mesenchymal stem cells (MSCs) can protect against cartilage breakdown in osteoarthritis
(OA) via their immunomodulatory capacities. However, the optimization strategy for using …
(OA) via their immunomodulatory capacities. However, the optimization strategy for using …
Identification of mesenchymal stem cells derived from rheumatoid arthritis synovial fluid and their regulatory effect on osteoblast formation
H Zhu, XX Jiang, Y Wu, YL Liu, XS Li… - … shi yan xue ye xue za …, 2009 - europepmc.org
This study was purposed to investigate the influence of inflammatory microenvironment on
mesenchymal stem cells (MSCs) and regulatory effect of MSCs on osteoblast formation. The …
mesenchymal stem cells (MSCs) and regulatory effect of MSCs on osteoblast formation. The …
[HTML][HTML] Bone marrow contribution to synovial hyperplasia following joint surface injury
A Sergijenko, AJ Roelofs, AHK Riemen… - Arthritis Research & …, 2016 - Springer
Background Joint surface injury, a known risk factor for osteoarthritis, triggers synovial
hyperplasia, which involves proliferation of mesenchymal stromal/stem cells (MSCs) …
hyperplasia, which involves proliferation of mesenchymal stromal/stem cells (MSCs) …
Check-control of inflammation displayed by bone marrow mesenchymal stem cells in rheumatoid arthritis patients
JR Lamas, A Mucientes, C Lajas… - …, 2019 - Taylor & Francis
Background: Mesenchymal stem cells (MSCs) are a promising treatment of different
musculoskeletal diseases including osteoarthritis and rheumatoid arthritis (RA). Results from …
musculoskeletal diseases including osteoarthritis and rheumatoid arthritis (RA). Results from …
[HTML][HTML] Detrimental alteration of mesenchymal stem cells by an articular inflammatory microenvironment results in deterioration of osteoarthritis
M Fan, P Tong, L Yan, T Li, J Ren, J Huang, W Du… - BMC medicine, 2023 - Springer
Background Articular injection of mesenchymal stem cells (MSCs) has been applied to treat
knee osteoarthritis (kOA), but its clinical outcomes are controversial. This study investigated …
knee osteoarthritis (kOA), but its clinical outcomes are controversial. This study investigated …
[HTML][HTML] Use of immune modulation by human adipose-derived mesenchymal stem cells to treat experimental arthritis in mice
L Zhang, XY Wang, PJ Zhou, Z He, HZ Yan… - American Journal of …, 2017 - ncbi.nlm.nih.gov
Rheumatoid arthritis is a chronic and systemic autoimmune disease characterized by
inflammatory cell infiltration and joint erosion. Human adipose-derived mesenchymal stem …
inflammatory cell infiltration and joint erosion. Human adipose-derived mesenchymal stem …
[HTML][HTML] Mesenchymal stem cells as a valuable agent in osteoarthritis treatment
M Sheykhhasan, H Manoochehri… - Stem Cell …, 2018 - sci.amegroups.org
Osteoarthritis (OA), a common disease that originates from cartilage damage, affects
approximately 250 million people around the world (1). The disease is more common in …
approximately 250 million people around the world (1). The disease is more common in …
Anti-inflammatory role and immunomodulation of mesenchymal stem cells in systemic joint diseases: potential for treatment
RJ MacFarlane, SM Graham, PSE Davies… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Mesenchymal stem cells (MSCs) are multipotent stromal cells characterized by
their ability to differentiate into adipocytes, chondrocytes, osteocytes and a number of other …
their ability to differentiate into adipocytes, chondrocytes, osteocytes and a number of other …