Mesenchymal stem cell therapy for osteoarthritis: how apoptotic cells modulate inflammation

P Mancuso, AJ Burke, S Raman, AE Ryan… - Osteoarthritis and …, 2018 - oarsijournal.com
Purpose: Mesenchymal stem cells (MSCs) enhance regeneration when locally delivered in
pre-clinical models of osteoarthritis (OA). Their mechanism of action, however, is still poorly …

Mesenchymal stem cell antigenicity is suppressed in an inflamed joint environment

J Hill, J Cassano, M Goodale… - Osteoarthritis and …, 2017 - oarsijournal.com
Purpose: Osteoarthritis (OA) is one of the leading causes of decreased athletic performance
in people and horses. Treatment with autologous mesenchymal stem cells (MSCs) has been …

Paradoxical effects of human adipose tissue-derived mesenchymal stem cells on progression of experimental arthritis in SKG mice

JH Kim, YT Lee, K Oh, J Cho, DS Lee, Y Hwang - Cellular immunology, 2014 - Elsevier
We evaluated the therapeutic effect of human adipose tissue-derived mesenchymal stem
cells (hAd-MSCs) in a SKG arthritis model, a relevant animal model for human rheumatoid …

[HTML][HTML] Effects of mesenchymal stem cells on interleukin-1β-treated chondrocytes and cartilage in a rat osteoarthritic model

J Tang, W Cui, F Song, C Zhai… - Molecular …, 2015 - spandidos-publications.com
In the present study, the effects and mechanisms of mesenchymal stem cells (MSCs) on
interleukin (IL)-1β‑stimulated rat chondrocytes, as well as cartilage from a rat model of …

Mesenchymal stem cells in synovial fluid increase in number in response to synovitis and display more tissue-reparative phenotypes in osteoarthritis

H Furuoka, K Endo, I Sekiya - Stem Cell Research & Therapy, 2023 - Springer
Background Synovial fluid mesenchymal stem cells (SF-MSCs) originate in the synovium
and contribute to the endogenous repair of damaged intra-articular tissues. Here, we …

Mesenchymal stromal cell immunology for efficient and safe treatment of osteoarthritis

M Najar, J Martel-Pelletier, JP Pelletier… - Frontiers in cell and …, 2020 - frontiersin.org
Mesenchymal stem cell (MSC) therapy represents a promising approach for the treatment of
osteoarthritis (OA). MSCs can be readily isolated from multiple sources and expanded ex …

Allogeneic murine mesenchymal stem cells: migration to inflamed joints in vivo and amelioration of collagen induced arthritis when transduced to express CTLA4Ig

C Sullivan, F Barry, T Ritter, C O'Flatharta… - Stem Cells and …, 2013 - liebertpub.com
Despite the immunosuppressive, homing, and regenerative capabilities of mesenchymal
stem cells (MSCs), their ability to migrate to arthritic joints and influence the course of …

[PDF][PDF] Human mesenchymal stem cells as a tool for joint repair in rheumatoid arthritis

Y Tanaka - Clin Exp Rheumatol, 2015 - clinexprheumatol.org
Rheumatoid arthritis (RA) is characterised with chronic inflammatory synovitis and
progressive joint. Because damaged and/or deformed joints cannot be repaired, a novel …

Administering human adipose-derived mesenchymal stem cells to prevent and treat experimental arthritis

B Zhou, J Yuan, Y Zhou, M Ghawji Jr, YP Deng… - Clinical …, 2011 - Elsevier
Rheumatoid arthritis is a chronic autoimmune disease and affecting approximately 1% of the
population. Human adipose-derived mesenchymal stem cells (hASCs) were recently found …

Therapeutic potential of autologous mesenchymal stem cells derived from synovial fluid in patients with degenerative arthritis

W Chang, SI Park, SY Jun, EJ Lee, H Ham… - Animal Cells and …, 2013 - Taylor & Francis
The possibility to isolate synovial fluid-derived mesenchymal stem cells (SFMSCs) from
patients with degenerative arthropathy has been an interest since synovial fluid (SF) from …