Concentrated Ambient Induced Inflammation and Endothelial Dysfunction in a Murine Model of Neural IKK2 Deficiency
M Chen, X Qin, L Qiu, S Chen, H Zhou… - Environmental …, 2018 - ehp.niehs.nih.gov
Background: Exposure to ambient fine particulate matter (PM 2.5) is associated with
cardiovascular mortality, but underlying pathophysiologic mechanisms are not fully …
cardiovascular mortality, but underlying pathophysiologic mechanisms are not fully …
IKK inhibition prevents PM2. 5-exacerbated cardiac injury in mice with type 2 diabetes
J Zhao, C Liu, Y Bai, T Wang, H Kan, Q Sun - Journal of Environmental …, 2015 - Elsevier
Epidemiological studies have found that individuals with diabetes mellitus (DM) display an
increased susceptibility for adverse cardiovascular outcomes when exposed to air pollution …
increased susceptibility for adverse cardiovascular outcomes when exposed to air pollution …
Central IKK2 inhibition ameliorates air pollution-mediated hepatic glucose and lipid metabolism dysfunction in mice with type II diabetes
Q Sun, G Zhang, R Chen, R Li, H Wang… - Toxicological …, 2018 - academic.oup.com
Previous studies supported a role of hypothalamic inflammation in fine ambient particulate
matter (PM2. 5) exposure-mediated diabetes development. We therefore investigated the …
matter (PM2. 5) exposure-mediated diabetes development. We therefore investigated the …
Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes
Background Prior experimental and epidemiologic data support a link between exposure to
fine ambient particulate matter (< 2.5 μm in aerodynamic diameter, PM 2.5) and …
fine ambient particulate matter (< 2.5 μm in aerodynamic diameter, PM 2.5) and …
Notch1-mediated inflammation is associated with endothelial dysfunction in human brain microvascular endothelial cells upon particulate matter exposure
JH Park, JY Choi, HK Lee, C Jo, YH Koh - Archives of Toxicology, 2021 - Springer
Exposure to atmospheric particulate matter (PM) is an emerging risk factor for the
pathogenesis of several diseases in humans, including cerebrovascular diseases. However …
pathogenesis of several diseases in humans, including cerebrovascular diseases. However …
Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM2. 5
Background Exposure to ambient fine particulate matter (PM 2.5) is associated with
increased cardiometabolic morbidity and mortality. This is widely believed to be attributable …
increased cardiometabolic morbidity and mortality. This is widely believed to be attributable …
Ambient fine particulate matter induced the elevation of blood pressure through ACE2/Ang (1–7) pathway: the evidence from urine metabolites
X Du, X Zeng, J Zhang, K Pan, L Song, J Zhou… - Ecotoxicology and …, 2020 - Elsevier
Background Exposure to ambient fine particulate matter (PM 2.5) is associated with various
adverse health outcomes. Although several mechanisms have been proposed including …
adverse health outcomes. Although several mechanisms have been proposed including …
Autophagy Induced FHL2 Upregulation Promotes IL-6 Production by Activating the NF-κB Pathway in Mouse Aortic Endothelial Cells after Exposure to PM2.5
WR Xia, W Fu, Q Wang, X Zhu, WW Xing… - International journal of …, 2017 - mdpi.com
Epidemiological and clinical studies have increasingly shown that fine particulate matter
(PM2. 5) is associated with cardiovascular morbidity and mortality, which share the common …
(PM2. 5) is associated with cardiovascular morbidity and mortality, which share the common …
Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways
T Kampfrath, A Maiseyeu, Z Ying, Z Shah… - Circulation …, 2011 - Am Heart Assoc
Rationale: Chronic exposure to ambient air-borne particulate matter of< 2.5 μm (PM2. 5)
increases cardiovascular risk. The mechanisms by which inhaled ambient particles are …
increases cardiovascular risk. The mechanisms by which inhaled ambient particles are …
[HTML][HTML] PM2. 5 increases mouse blood pressure by activating toll-like receptor 3
J Zhang, R Chen, G Zhang, Y Wang, J Peng… - Ecotoxicology and …, 2022 - Elsevier
Background and aims Plenty of literature has documented that fine particulate matter (PM
2.5) exposure is related to blood pressure (BP) elevation. Vascular dysfunction is the …
2.5) exposure is related to blood pressure (BP) elevation. Vascular dysfunction is the …