PTEN function: how normal cells control it and tumour cells lose it
NR Leslie, CP Downes - Biochemical Journal, 2004 - portlandpress.com
The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …
[HTML][HTML] PTEN: multiple functions in human malignant tumors
M Milella, I Falcone, F Conciatori, U Cesta Incani… - Frontiers in …, 2015 - frontiersin.org
PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …
The functions and regulation of the PTEN tumour suppressor: new modes and prospects
PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
[HTML][HTML] Regulation of PTEN Phosphorylation and Stability by a Tumor Suppressor Candidate Protein*♦
F Okahara, H Ikawa, Y Kanaho, T Maehama - Journal of Biological …, 2004 - ASBMB
The tumor suppressor PTEN plays an essential role in regulating signaling pathways
involved in cell growth and apoptosis and is inactivated in a wide variety of tumors. In this …
involved in cell growth and apoptosis and is inactivated in a wide variety of tumors. In this …
Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways …
The tumour suppressor protein, PTEN (phosphatase and tensin homolog deleted on
chromosome 10), is a phosphatase that can dephosphorylate tyrosine-containing peptides …
chromosome 10), is a phosphatase that can dephosphorylate tyrosine-containing peptides …
PTEN: from pathology to biology
ML Sulis, R Parsons - Trends in cell biology, 2003 - cell.com
The PTEN tumour suppressor gene is mutated frequently in many malignancies and its
importance in the development of cancer is probably underestimated. As the primary …
importance in the development of cancer is probably underestimated. As the primary …
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif
SM Walker, NR Leslie, NM Perera, IH Batty… - Biochemical …, 2004 - portlandpress.com
The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour-
suppressor protein is a phosphoinositide 3-phosphatase which antagonizes …
suppressor protein is a phosphoinositide 3-phosphatase which antagonizes …
PTEN: its deregulation and tumorigenesis
T Maehama - Biological and Pharmaceutical Bulletin, 2007 - jstage.jst.go.jp
The tumor suppressor phosphatase and tensin homolog (PTEN) functions as a
phosphoinositide 3-phosphatase, that antagonizes phosphatidylinositol 3-kinase action, and …
phosphoinositide 3-phosphatase, that antagonizes phosphatidylinositol 3-kinase action, and …
Post-translational regulation of PTEN
X Wang, X Jiang - Oncogene, 2008 - nature.com
PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor
regulates a variety of cellular processes including cell proliferation, growth, migration and …
regulates a variety of cellular processes including cell proliferation, growth, migration and …
PTEN proteoforms in biology and disease
Proteoforms are specific molecular forms of protein products arising from a single gene that
possess different structures and different functions. Therefore, a single gene can produce a …
possess different structures and different functions. Therefore, a single gene can produce a …