Background Group 2 innate lymphoid cells (ILC2s) are important mediators of allergic
asthma. Bacterial components, such as unmethylated CpG DNA, a Toll-like receptor (TLR) 9 …

Group 2 innate lymphoid cells (ILC2s) play an important role in the pathophysiology of
asthma via the robust production of type 2 cytokines. Recent studies have demonstrated that …

Background Type 2 innate lymphoid cells (ILC2s) are one of the sources of IL‐5 and IL‐13 in
allergic airway inflammation. Innate immune receptors such as Toll‐like receptors (TLRs) …

Rationale: Toll-like receptor (TLR) 7/8 ligands are promising candidate drugs for the
treatment of allergic asthma and rhinitis. Although their clinical application depends on the …

Allergic asthma is a chronic inflammatory disease predominately associated with the
activation of CD4+ T helper Type 2 (Th2) cells. Innate pattern recognition receptors are …

Group 2 innate lymphoid cells (ILC2) are implicated in allergic asthma as an early innate
source of the type 2 cytokines IL-5 and IL-13. However, their induction in house dust mite …

Background Group 2 innate lymphoid cells (ILC2s) are involved in type 2 immune responses
in mucosal organs and are associated with various allergic diseases in humans. Studies are …

T helper type 2 cells (Th2 cells) and group 2 innate lymphoid cells (ILC2s) play an important
role in the pathophysiology of asthma, including airway eosinophilic inflammation. ILC2s are …

The recent discovery of group 2 innate lymphoid cells (ILC2s) has caused a paradigm shift
in the understanding of allergic airway disease pathogenesis. Prior to the discovery of …

Background Group 2 innate lymphoid cells (ILC2s) are the dominant innate lymphoid cell
population in the lungs at steady state, and their release of type 2 cytokines is a central …