Skp2 is a crucial component of SCFSkp2 E3 ubiquitin ligase and is often overexpressed in
various types of cancer, including prostate cancer (PCa). The epithelial-to-mesenchymal …

Osteosarcoma (OS) is a common bone tumor that mainly affects children and young adults.
S-phase kinase‑associated protein 2 (Skp2) has been characterized to play a critical …

Skp2 E3 ligase is overexpressed in numerous human cancers and plays a critical role in cell-
cycle progression, senescence, metabolism, cancer progression, and metastasis. In the …

BACKGROUND: In several human cancers, overexpression of Skp2 (S-phase kinase
associated protein 2), which targets p27 for degradation, portends a poorer prognosis. We …

Prostate cancer is the most frequently diagnosed tumor in men and the second most
common cause of cancer-related death for males in the United States. It has been shown …

SKP2, an F-box protein of the SCF type of the E3 ubiquitin ligase complex, plays an
important function in driving tumorigenesis through the destruction of numerous tumor …

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men in
Western countries, and there is still an urgent need for a better understanding of PCa …

Prostate cancer is the most commonly diagnosed tumor in men in the United States. Patients
with hormone-refractory prostate cancer are often treated with paclitaxel, but most of them …

Osteosarcoma (OS), the most common primary cancer of bone, exhibits a high propensity for
local invasion and distant metastasis. This study sought to elucidate the role of S phase …

BACKGROUND Overexpression of serine protease inhibitor Kazal type 1 (SPINK1) defines
an aggressive molecular subtype of ETS fusion‐negative prostate cancer (PCa) patients in …