In order to better understand how ambient air particulate matter (PM) affect lung health, the
two main airway cell types likely to interact with inhaled particles, alveolar macrophages …

Primary cultures of normal human airway epithelial cells (NHBE) respond to ambient air
pollution particulate matter (PM) by increased production of the cytokine IL-8, and the …

Exposure to ambient air pollution particles with a diameter of< 10 μ m (PM10) has been
associated with increased cardiopulmonary morbidity and mortality. We postulate that these …

Inhalation of particulate matter in the ambient air has been shown to cause pulmonary
morbidity and exacerbate asthma. Alveolar macrophage (AM) are essential for effective …

Fine and coarse air pollution particles signal macrophage activation via differential
utilization of Toll-like receptors (TLR) 2 and TLR4 but shared use of the MyD88 signaling …

Exposure to ambient air pollution particles (PM) has been associated with increased
cardiopulmonary morbidity and mortality, particularly in individuals with pre-existing disease …

Inhalation of particulate matter (PM) may result in exacerbation of inflammatory airways
disease, including asthma. Results from this laboratory have shown that the coarse …

Alveolar macrophages (AM) play a key role in clearing atmospheric particulates from the
lung surface and stimulating epithelial cells to produce proinflammatory mediators. The …

Interactions between alveolar macrophages (AMs) and epithelial cells may promote
inflammatory responses to air pollution particles. Normal rat AMs, the alveolar type II …

In the lower airways, macrophages are important regulators of inflammation and
indispensable in their antimicrobial activities. Thus, air pollution particles, which modulate …