Background and Purpose—The aim of this study was to explore the possible contribution of
alterations in cerebral hemodynamics to the evolution of cognitive impairment in patients …

The concept of Vascular Cognitive Impairment (VCI) encompasses patients across the entire
continuum of cognitive impairment resulting from cerebrovascular disease (CVD), ranging …

Hachinski and co-workers have used the term vascular cognitive impairment—no dementia
(VaCIND) to represent the earliest stages of cognitive decline associated with vascular …

Background: Normal aging is associated with a decline in cognitive abilities, particularly in
the domains of psychomotor speed and executive functioning. However,'aging,'per se, is not …

Background and Purpose—We hypothesized that comorbid amyloid-beta (Aβ) deposition
played a key role in long-term cognitive decline in subjects with stroke/transient ischemic …

To determine whether white matter network disruption mediates the association between
MRI markers of cerebrovascular disease (CeVD) and cognitive impairment. Participants (n …

Objective: Vascular risk factors in mid-life predict late life cognitive decline in previously
normal populations. We sought to investigate the contribution of vascular risk factors in late …

The prevalence, morphology and pathogenesis of vascular dementia (VaD), recently termed
vascular cognitive impairment (VCI), and of mixed dementia (Alzheimer disease+ vascular …

Objective To determine whether vascular and neurodegenerative factors influence cognition
before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and …

Background: White matter lesions (WMLs), asymptomatic lacunar infarcts, brain microbleeds
(BMBs), and enlarged perivascular spaces (EPVS) have been identified as silent lesions …