The gasdermin family of pore-forming proteins (PFPs) has recently emerged as key
molecular players controlling immune-related cell death in mammals. Characterized …

Gasdermins have been identified as playing a prominent role in the innate immune
response as the executors of a specific type of cell death called pyroptosis. Specific …

In the recent past, the concept of immunity has been extended to eukaryotic and prokaryotic
microorganisms, like fungi and bacteria. The latest findings have drawn remarkable …

The gasdermins are a family of pore-forming proteins involved in various cellular processes
such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary …

The pore-forming gasdermin proteins mediate a lytic and proinflammatory form of cell death
called pyroptosis and have been linked to the host defense against infection. Two recent …

Gasdermins are proteins that can self-assemble into membrane channels (also known as
pores). These pores can serve as conduits for the secretion of cytosolic molecules, with the …

The family of gasdermin proteins plays a key role in the host response against external and
internal pathogenic signals by mediating the form of inflammatory regulated cell death …

A defining feature of multicellular life is the utilization of programmed cell death (PCD)[1]. By
sacrificing nonessential cells, the PCD machinery of multicellular eukaryotes defends …

The gasdermin family is a newly identified class of pore-forming proteins that play as the
executioners of pyroptosis, a lytic pro-inflammatory type of cell death triggered by sensing …

The gasdermins are a family of recently identified pore-forming effector proteins that cause
membrane permeabilization and pyroptosis, a lytic pro-inflammatory type of cell death …