Significance: Heme degradation, which was described more than 30 years ago, is still very
actively explored with many novel discoveries on its role in various disease models every …

The heme oxygenase (HO) system is essential for heme and iron homeostasis and
necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon …

HO-1 (haem oxygenase-1) is a ubiquitously expressed inducible enzyme degrading haem
to CO, biliverdin and Fe2+. Its activation reduces oxidative stress in cells and inhibits …

Heme-oxygenase is the enzyme responsible for degradation of endogenous iron
protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of …

Heme is a molecule that is synthesized by the sequential actions of eight enzymes and is
ubiquitous throughout nature. For many years it has been known that heme is also …

Hemeoxygenase (HO) system is responsible for cellular heme degradation to biliverdin,
iron, and carbon monoxide. Two isoforms have been reported to date. Homologous HO‐1 …

The heme molecule serves as an essential prosthetic group for oxygen transport and
storage proteins, as well for cellular metabolic enzyme activities, including those involved in …

Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that catabolizes free heme into
carbon monoxide, iron (which induces the expression of heavy-chain ferritin, an iron …

A large amount of hemoglobin is degraded daily to heme and globin and is replenished by
biosynthesis in the bone marrow erythroblasts.“Free heme” can be dissociated from …

The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …