ymptomatic heart failure and sudden cardiac death are worldwide health problems. In the
hopes of reducing S the morbidity and mortality associated with myocardial failure and …

The interstitium of the myocardium is composed of predominantly type I collagen; type III
collagen is present to a lesser extent. The fibrillar collagens serve as tethers between …

Myocardial fibrosis can be defined as an abnormal increase in collagen concentration of
either ventricle. This accumulation of collagen, represented predominantly by fibrillar type I …

The major risk factor associated with the appearance of adverse cardiovascular events and
outcome attributable to cardiovascular disease is left ventricular hypertrophy (LVH). Why this …

Changes in the composition of cardiac tissue develop in hypertensive patients with left
ventricular hypertrophy (ie, hypertensive heart disease) and lead to structural remodeling of …

Myocardial fibrosis in hypertensive heart disease (HHD) can present as a reactive process,
involving intramyocardial coronary arteries and arterioles with extensions of collagen into …

Left ventricular hypertrophy (LVH) is the major risk factor associated with myocardial failure.
An explanation for why a presumptive adaptation such as LVH would prove pathological has …

Myocardial fibrosis is a frequently observed pathologic finding. It is a common practice to
differentiate macroscopic scarring and microscopic scarring, but there has been little attempt …

The accumulation of collagen within the myocardium is termed fibrosis. In left ventricular
pressure overload a reactive interstitial fibrosis, having distinctive biochemical and structural …

Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …