Treatment-resistant depression (TRD) is a common clinical occurrence among patients
treated for major depressive disorder. However, a clear consensus regarding the criteria …

Treatment-resistant depression (TRD) typically refers to inadequate response to at least one
antidepressant trial of adequate doses and duration. TRD is a relatively common occurrence …

Treatment-resistant depression (TRD) is a major public health problem in terms of its
prevalence and in terms of individual suffering and cost to society. Best estimates indicate …

Our ability to treat depression has improved with the availability of receptor-specific and
chemically diverse groups of antidepressants. Even now, most of the short-term studies …

A wide variety of definitions are used for Treatment Resistant Depression (TRD), considering
various criteria and different concepts. Some of the key issues are: the diagnosis, the …

BACKGROUND: Despite the common occurrence and debilitating nature of treatment-
resistant depression (TRD), currently there is no universally accepted definition for TRD …

Objective: No universal definition for treatment-resistant depression (TRD) exists. This lack
of consensus reduces the generalizability of study findings and limits the ability to study …

The concept of treatment-resistant or treatment-refractory depression (TRD) has evolved
over 40 years since the recognition that some patients minimally benefit from repeated …

Background Major depressive disorder is a common, recurrent, disabling and costly disorder
that is often severe and/or chronic, and for which non-remission on guideline concordant first …

Abstract Treatment-resistant depression (TRD) is a subset of Major Depressive Disorder
which does not respond to traditional and first-line therapeutic options. There are several …