Non-stationary discharge patterns in motor cortex under subthalamic nucleus deep brain stimulation

S Santaniello, EB Montgomery Jr, JT Gale… - Frontiers in integrative …, 2012 - frontiersin.org
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) directly modulates the basal
ganglia (BG), but how such stimulation impacts the cortex upstream is largely unknown …

Network effects of subthalamic deep brain stimulation drive a unique mixture of responses in basal ganglia output

MD Humphries, K Gurney - European journal of neuroscience, 2012 - Wiley Online Library
Deep brain stimulation (DBS) is a remarkably successful treatment for the motor symptoms
of Parkinson's disease. High‐frequency stimulation of the subthalamic nucleus (STN) within …

Direct activation of primary motor cortex during subthalamic but not pallidal deep brain stimulation

LA Johnson, J Wang, SD Nebeck, J Zhang… - Journal of …, 2020 - Soc Neuroscience
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus
(GPi) is an effective treatment for parkinsonian motor signs. Though its therapeutic …

The role of neurotransmitter systems in mediating deep brain stimulation effects in Parkinson's disease

F Alosaimi, JT Boonstra, S Tan, Y Temel… - Frontiers in …, 2022 - frontiersin.org
Deep brain stimulation (DBS) is among the most successful paradigms in both translational
and reverse translational neuroscience. DBS has developed into a standard treatment for …

Subthalamic deep brain stimulation reduces pathological information transmission to the thalamus in a rat model of parkinsonism

CJ Anderson, DT Sheppard, R Huynh… - Frontiers in Neural …, 2015 - frontiersin.org
The degeneration of dopaminergic neurons in the substantia nigra pars compacta leads to
parkinsonian motor symptoms via changes in electrophysiological activity throughout the …

Model-based deconstruction of cortical evoked potentials generated by subthalamic nucleus deep brain stimulation

K Kumaravelu, CS Oza… - Journal of …, 2018 - journals.physiology.org
Parkinson's disease is associated with altered neural activity in the motor cortex. Chronic
high-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in …

Stimulation of cortico-subthalamic projections amplifies resting motor circuit activity and leads to increased locomotion in dopamine-depleted mice

TH Sanders - Frontiers in integrative neuroscience, 2017 - frontiersin.org
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor function in
patients with Parkinson's disease (PD). STN-DBS enables similar improved motor function …

Dynamic stereotypic responses of basal ganglia neurons to subthalamic nucleus high-frequency stimulation in the parkinsonian primate

A Moran, E Stein, H Tischler, K Belelovsky… - Frontiers in systems …, 2011 - frontiersin.org
Deep brain stimulation (DBS) in the subthalamic nucleus (STN) is a well-established therapy
for patients with severe Parkinson's disease (PD); however, its mechanism of action is still …

Patterned low-frequency deep brain stimulation induces motor deficits and modulates cortex-basal ganglia neural activity in healthy rats

CS Oza, DT Brocker, CE Behrend… - Journal of …, 2018 - journals.physiology.org
Deep brain stimulation (DBS) is an effective therapy for movement disorders, including
Parkinson's disease (PD), although the mechanisms of action remain unclear. Abnormal …

Multiple stimulation parameters influence efficacy of deep brain stimulation in parkinsonian mice

JS Schor, AB Nelson - The Journal of clinical investigation, 2019 - Am Soc Clin Investig
Deep brain stimulation (DBS) is used to treat multiple neuropsychiatric disorders, including
Parkinson's disease (PD). Despite widespread clinical use, its therapeutic mechanisms are …