Frequency of p16INK4A alterations and k-ras mutations in intrahepatic cholangiocarcinoma of the liver
A Tannapfel, M Benicke, A Katalinic, D Uhlmann… - Gut, 2000 - gut.bmj.com
BACKGROUND Inactivation of the tumour suppressor gene p16 (CDKN2/MTS-1/INK4A) and
K-ras mutations are among the most frequent genetic alterations in human malignancies …
K-ras mutations are among the most frequent genetic alterations in human malignancies …
High frequency of p16INK4A gene alterations in hepatocellular carcinoma
The tumor suppressor gene p16 (CDKN2/MTS-1/INK4A) is an important component of the
cell cycle and inactivation of the gene has been found in a variety of human cancers. In …
cell cycle and inactivation of the gene has been found in a variety of human cancers. In …
p16INK4 is inactivated by extensive CpG methylation in human hepatocellular carcinoma
Y Matsuda, T Ichida, J Matsuzawa, K Sugimura… - Gastroenterology, 1999 - Elsevier
Background & Aims: The molecular status of the p16INK4 tumor-suppressor gene has not
been fully elucidated in hepatocellular carcinoma. The aim of this study was to clarify the …
been fully elucidated in hepatocellular carcinoma. The aim of this study was to clarify the …
Immunohistochemical p16INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene: a comparison of four commercial …
J Geradts, RH Hruban, M Schutte… - Applied …, 2000 - journals.lww.com
Abstract The MTS1/CDKN2/p16 gene encoding the p16 INK4a tumor-suppressor protein is
commonly inactivated by homozygous deletion or hypermethylation of the promoter in a …
commonly inactivated by homozygous deletion or hypermethylation of the promoter in a …
Hypermethylation of the CDKN2/p16 promoter during neoplastic progression in Barrett's esophagus
B Klump, CJ Hsieh, K Holzmann, M Gregor… - Gastroenterology, 1998 - Elsevier
Background & Aims: Inactivation of the CDKN2/p16INK4A tumor-suppressor gene is one of
the most frequent genetic alterations in human malignancies. In esophageal …
the most frequent genetic alterations in human malignancies. In esophageal …
Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 Genes in Biliary Tract Cancers
S Yoshida, T Todoroki, Y Ichikawa, S Hanai, H Suzuki… - Cancer research, 1995 - AACR
Abstract p16Ink4 and p15Ink4B are cyclin-dependent kinase 4 inhibitors and link to the
regulation of cell cycle in mammalian cells. The genes encoding these inhibitors are located …
regulation of cell cycle in mammalian cells. The genes encoding these inhibitors are located …
[HTML][HTML] Alterations of tumor suppressor gene p16 INK4a in pancreatic ductal carcinoma
J Attri, R Srinivasan, S Majumdar, BD Radotra… - BMC …, 2005 - Springer
Background Cell cycle inhibitor and tumor suppressor gene p16/MTS-1 has been reported
to be altered in a variety of human tumors. The purpose of the study was to evaluate primary …
to be altered in a variety of human tumors. The purpose of the study was to evaluate primary …
p16 is a major inactivation target in hepatocellular carcinoma
Abstract BACKGROUND The p16INK4A gene encodes 2 cell cycle regulator proteins, p16
and p14ARF, by alternative splicing. This genetic locus also contains another cell cycle …
and p14ARF, by alternative splicing. This genetic locus also contains another cell cycle …
Germ-line mutations of thep16INK4 (MTS1) gene occur in a subset of patients with hepatocellular carcinoma
P Chaubert, R Gayer, A Zimmermann, C Fontolliet… - Hepatology, 1997 - journals.lww.com
The molecular mechanisms of hepatocarcinogenesis are poorly understood. Only very
recently has there been a suggestion of familial hepatocellular carcinoma (HCC). We have …
recently has there been a suggestion of familial hepatocellular carcinoma (HCC). We have …
p16INK4A Hypermethylation Is Associated with Hepatitis Virus Infection, Age, and Gender in Hepatocellular Carcinoma
X Li, AM Hui, L Sun, K Hasegawa, G Torzilli… - Clinical Cancer …, 2004 - AACR
Purpose: The tumor suppressor gene p16INK4A is mainly inactivated by an epigenetic
change involving promoter hypermethylation in hepatocarcinogenesis. The possible clinical …
change involving promoter hypermethylation in hepatocarcinogenesis. The possible clinical …