Novel antitumor adamantane–azole gold (I) complexes as potential inhibitors of thioredoxin reductase

A Garcia, RC Machado, RM Grazul, MTP Lopes… - JBIC Journal of …, 2016 - Springer
Gold complexes that could act as antitumor agents have attracted great attention.
Heterocyclic compounds and their metal complexes display a broad spectrum of …

Synthesis and characterization of azolate gold (I) phosphane complexes as thioredoxin reductase inhibiting antitumor agents

R Galassi, A Burini, S Ricci, M Pellei… - Dalton …, 2012 - pubs.rsc.org
Following an increasing interest in the gold drug therapy field, nine new neutral azolate gold
(I) phosphane compounds have been synthesized and tested as anticancer agents. The …

Benzimidazol-2-ylidene gold (I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties

R Rubbiani, I Kitanovic, H Alborzinia… - Journal of medicinal …, 2010 - ACS Publications
Gold (I) complexes such as auranofin have been used for decades to treat symptoms of
rheumatoid arthritis and have also demonstrated a considerable potential as new anticancer …

NHC gold halide complexes derived from 4, 5-diarylimidazoles: synthesis, structural analysis, and pharmacological investigations as potential antitumor agents

W Liu, K Bensdorf, M Proetto, U Abram… - Journal of medicinal …, 2011 - ACS Publications
A series of novel neutral NHC gold halide complexes derived from 4, 5-diarylimidazoles
were synthesized, characterized, and analyzed for biological effects. High growth inhibitory …

Synthesis and biological evaluation of thiolate gold (i) complexes as thioredoxin reductase (TrxR) and glutathione reductase (GR) inhibitors

M Fereidoonnezhad, HA Mirsadeghi… - New Journal of …, 2019 - pubs.rsc.org
New gold (I) thiolate complexes [(PPh2py) Au (SR)](PPh2py= 2-(diphenylphosphino)
pyridine and SR= the deprotonated form of pyridine-2-thiol (HSpy, 1a), pyrimidine-2 thiol …

Gold (I) thiotetrazolates as thioredoxin reductase inhibitors and antiproliferative agents

TV Serebryanskaya, AS Lyakhov, LS Ivashkevich… - Dalton …, 2015 - pubs.rsc.org
Gold (I) complexes with phosphane and thiotetrazolate ligands were prepared and
investigated as a new type of bioactive gold metallodrugs. The complexes triggered very …

Density functional theory study of gold (III)-dithiocarbamate complexes with characteristic anticancer potentials

MM Lawal, IA Lawal, MJ Klink, GF Tolufashe… - Journal of inorganic …, 2020 - Elsevier
The application of gold as drug candidate dated back to 2500 BC and its relevance in
medicine became more appealing following 1985 FDA approval of ingested Auranofin for …

Synthesis, X-ray structures and anticancer activity of gold (I)-carbene complexes with selenones as co-ligands and their molecular docking studies with thioredoxin …

AAA Seliman, M Altaf, AT Onawole, S Ahmad… - Journal of …, 2017 - Elsevier
Five new gold (I) complexes of carbene and selenone ligands (1–5) having the general
formula,[Au (IPr)(selenone)] PF 6 were synthesized by the reaction of [Au (IPr) Cl](0) with …

Gold (I) complexes with a quinazoline carboxamide alkynyl ligand: Synthesis, cytotoxicity, and mechanistic studies

L Tabrizi, WS Yang, C Chintha… - European Journal of …, 2021 - Wiley Online Library
A series of gold (I) complexes with the general formula [Au (L2)(L′)](L2= 4‐phenyl‐N‐(prop‐
2‐yn‐1‐yl) quinazoline‐2‐carboxamide, L′= PPh3 (triphenylphosphine), 1; TPA (1, 3, 5 …

Gold (I) carbene complexes causing thioredoxin 1 and thioredoxin 2 oxidation as potential anticancer agents

E Schuh, C Pflüger, A Citta, A Folda… - Journal of medicinal …, 2012 - ACS Publications
Gold (I) complexes with 1, 3-substituted imidazole-2-ylidene and benzimidazole-2-ylidene
ligands of the type NHC-Au-L (NHC= N-heterocyclic carbene L= Cl or 2-mercapto …