Novel antitumor adamantane–azole gold (I) complexes as potential inhibitors of thioredoxin reductase
A Garcia, RC Machado, RM Grazul, MTP Lopes… - JBIC Journal of …, 2016 - Springer
Gold complexes that could act as antitumor agents have attracted great attention.
Heterocyclic compounds and their metal complexes display a broad spectrum of …
Heterocyclic compounds and their metal complexes display a broad spectrum of …
Synthesis and characterization of azolate gold (I) phosphane complexes as thioredoxin reductase inhibiting antitumor agents
Following an increasing interest in the gold drug therapy field, nine new neutral azolate gold
(I) phosphane compounds have been synthesized and tested as anticancer agents. The …
(I) phosphane compounds have been synthesized and tested as anticancer agents. The …
Benzimidazol-2-ylidene gold (I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties
R Rubbiani, I Kitanovic, H Alborzinia… - Journal of medicinal …, 2010 - ACS Publications
Gold (I) complexes such as auranofin have been used for decades to treat symptoms of
rheumatoid arthritis and have also demonstrated a considerable potential as new anticancer …
rheumatoid arthritis and have also demonstrated a considerable potential as new anticancer …
NHC gold halide complexes derived from 4, 5-diarylimidazoles: synthesis, structural analysis, and pharmacological investigations as potential antitumor agents
W Liu, K Bensdorf, M Proetto, U Abram… - Journal of medicinal …, 2011 - ACS Publications
A series of novel neutral NHC gold halide complexes derived from 4, 5-diarylimidazoles
were synthesized, characterized, and analyzed for biological effects. High growth inhibitory …
were synthesized, characterized, and analyzed for biological effects. High growth inhibitory …
Synthesis and biological evaluation of thiolate gold (i) complexes as thioredoxin reductase (TrxR) and glutathione reductase (GR) inhibitors
M Fereidoonnezhad, HA Mirsadeghi… - New Journal of …, 2019 - pubs.rsc.org
New gold (I) thiolate complexes [(PPh2py) Au (SR)](PPh2py= 2-(diphenylphosphino)
pyridine and SR= the deprotonated form of pyridine-2-thiol (HSpy, 1a), pyrimidine-2 thiol …
pyridine and SR= the deprotonated form of pyridine-2-thiol (HSpy, 1a), pyrimidine-2 thiol …
Gold (I) thiotetrazolates as thioredoxin reductase inhibitors and antiproliferative agents
Gold (I) complexes with phosphane and thiotetrazolate ligands were prepared and
investigated as a new type of bioactive gold metallodrugs. The complexes triggered very …
investigated as a new type of bioactive gold metallodrugs. The complexes triggered very …
Density functional theory study of gold (III)-dithiocarbamate complexes with characteristic anticancer potentials
The application of gold as drug candidate dated back to 2500 BC and its relevance in
medicine became more appealing following 1985 FDA approval of ingested Auranofin for …
medicine became more appealing following 1985 FDA approval of ingested Auranofin for …
Synthesis, X-ray structures and anticancer activity of gold (I)-carbene complexes with selenones as co-ligands and their molecular docking studies with thioredoxin …
AAA Seliman, M Altaf, AT Onawole, S Ahmad… - Journal of …, 2017 - Elsevier
Five new gold (I) complexes of carbene and selenone ligands (1–5) having the general
formula,[Au (IPr)(selenone)] PF 6 were synthesized by the reaction of [Au (IPr) Cl](0) with …
formula,[Au (IPr)(selenone)] PF 6 were synthesized by the reaction of [Au (IPr) Cl](0) with …
Gold (I) complexes with a quinazoline carboxamide alkynyl ligand: Synthesis, cytotoxicity, and mechanistic studies
L Tabrizi, WS Yang, C Chintha… - European Journal of …, 2021 - Wiley Online Library
A series of gold (I) complexes with the general formula [Au (L2)(L′)](L2= 4‐phenyl‐N‐(prop‐
2‐yn‐1‐yl) quinazoline‐2‐carboxamide, L′= PPh3 (triphenylphosphine), 1; TPA (1, 3, 5 …
2‐yn‐1‐yl) quinazoline‐2‐carboxamide, L′= PPh3 (triphenylphosphine), 1; TPA (1, 3, 5 …
Gold (I) carbene complexes causing thioredoxin 1 and thioredoxin 2 oxidation as potential anticancer agents
E Schuh, C Pflüger, A Citta, A Folda… - Journal of medicinal …, 2012 - ACS Publications
Gold (I) complexes with 1, 3-substituted imidazole-2-ylidene and benzimidazole-2-ylidene
ligands of the type NHC-Au-L (NHC= N-heterocyclic carbene L= Cl or 2-mercapto …
ligands of the type NHC-Au-L (NHC= N-heterocyclic carbene L= Cl or 2-mercapto …