Temporal transcriptome analysis reveals dynamic gene expression patterns driving β-cell maturation
Newly differentiated pancreatic β cells lack proper insulin secretion profiles of mature
functional β cells. The global gene expression differences between paired immature and …
functional β cells. The global gene expression differences between paired immature and …
[HTML][HTML] Deciphering pancreatic islet β cell and α cell maturation pathways and characteristic features at the single-cell level
Pancreatic β and α cells play essential roles in maintaining glucose homeostasis. However,
the mechanisms by which these distinct cell populations are generated, expand, and mature …
the mechanisms by which these distinct cell populations are generated, expand, and mature …
Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells
Diabetes cell replacement therapy has the potential to be transformed by human pluripotent
stem cell-derived β cells (SC-β cells). However, the precise identity of SC-β cells in …
stem cell-derived β cells (SC-β cells). However, the precise identity of SC-β cells in …
Pseudotemporal ordering of single cells reveals metabolic control of postnatal β cell proliferation
C Zeng, F Mulas, Y Sui, T Guan, N Miller, Y Tan, F Liu… - Cell metabolism, 2017 - cell.com
Pancreatic β cell mass for appropriate blood glucose control is established during early
postnatal life. β cell proliferative capacity declines postnatally, but the extrinsic cues and …
postnatal life. β cell proliferative capacity declines postnatally, but the extrinsic cues and …
Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system
S Sasaki, MYY Lee, Y Wakabayashi, L Suzuki… - Diabetologia, 2022 - Springer
Aims/hypothesis While pancreatic beta cells have been shown to originate from endocrine
progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and …
progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and …
[PDF][PDF] Transcriptome landmarks of the functional maturity of rat beta-cells, from lactation to adulthood
Research on the postnatal development of pancreatic beta-cells has become an important
subject in recent years. Understanding the mechanisms that govern beta-cell postnatal …
subject in recent years. Understanding the mechanisms that govern beta-cell postnatal …
Chronology of endocrine differentiation and beta-cell neogenesis
T Miyatsuka - Endocrine Journal, 2016 - jstage.jst.go.jp
Diabetes is a chronic and incurable disease, which results from absolute or relative insulin
insufficiency. Therefore, pancreatic beta cells, which are the only type of cell that expresses …
insufficiency. Therefore, pancreatic beta cells, which are the only type of cell that expresses …
[HTML][HTML] Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D
Objective Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …
Dynamic Ins2 Gene Activity Defines β-Cell Maturity States
CMJ Chu, H Modi, C Ellis, NAJ Krentz, S Skovsø… - Diabetes, 2022 - Am Diabetes Assoc
Transcriptional and functional cellular specialization has been described for insulin-
secreting β-cells of the endocrine pancreas. However, it is not clear whether β-cell …
secreting β-cells of the endocrine pancreas. However, it is not clear whether β-cell …
Transcriptional heterogeneity of beta cells in the intact pancreas
Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However,
spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging …
spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging …