Paradoxical roles of IL-4 in tumor immunity
Abstract Interleukin (IL)-4 is a crucial cytokine in tumor immunology. In the initial murine
experiments, IL-4 exhibited potent anti-tumor ability. Tumors genetically modified to produce …
experiments, IL-4 exhibited potent anti-tumor ability. Tumors genetically modified to produce …
Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis
The increase of interleukin-4 (IL-4) level in tumor environment and the up-regulation of IL-4
receptor (IL-4R) on tumor cells have been long observed. However, their significance for …
receptor (IL-4R) on tumor cells have been long observed. However, their significance for …
Expression of high-affinity IL-4 receptors on human melanoma, ovarian and breast carcinoma cells
NI Obiri, JP Siegel, F Varricchio… - Clinical & Experimental …, 1994 - academic.oup.com
It has previously been shown that murine sarcoma cells express high-affinity IL-4 receptors
(1L-4R) which are internalized after binding to the ligand (Puri et al., Cancer Res 1991; 51 …
(1L-4R) which are internalized after binding to the ligand (Puri et al., Cancer Res 1991; 51 …
Lack of interleukin‐6 in the tumor microenvironment augments type‐1 immunity and increases the efficacy of cancer immunotherapy
Y Ohno, Y Toyoshima, H Yurino, N Monma… - Cancer …, 2017 - Wiley Online Library
Conquering immunosuppression in tumor microenvironments is crucial for effective cancer
immunotherapy. It is well known that interleukin (IL)‐6, a pleiotropic cytokine, is produced in …
immunotherapy. It is well known that interleukin (IL)‐6, a pleiotropic cytokine, is produced in …
Interleukin 3 enhances development of tumor-reactive cytotoxic cells by a CD4-dependent mechanism
BA Pulaski, AJ McAdam, EK Hutter, S Biggar, EM Lord… - Cancer research, 1993 - AACR
We investigated the effects that mouse interleukin 3 (IL-3), in comparison to mouse IL-2, has
on the generation of cytotoxic effectors capable of killing line 1 tumor cells. These potent …
on the generation of cytotoxic effectors capable of killing line 1 tumor cells. These potent …
Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity
W Gao, S Kumar, MT Lotze, C Hanning… - The Journal of …, 2003 - journals.aai.org
Recently, several novel members of the IL-1 family have been identified. The possible
therapeutic utility and the underlying biologic role of these new members remain unclear. In …
therapeutic utility and the underlying biologic role of these new members remain unclear. In …
Interleukin 4 receptor expression and growth inhibition of gastric carcinoma cells by interleukin 4
T Morisaki, DH Yuzuki, RT Lin, LJ Foshag, DL Morton… - Cancer research, 1992 - AACR
The expression of the interleukin 4 (IL-4) receptor (IL-4R) and effects of human recombinant
IL-4 on human gastric carcinoma cell lines were studied. We demonstrated that IL-4 …
IL-4 on human gastric carcinoma cell lines were studied. We demonstrated that IL-4 …
Antitumor effect of interleukin (IL)-12 in the absence of endogenous IFN-γ: a role for intrinsic tumor immunogenicity and IL-15
IFN-γ knockout mice (GKO) rejected C26 colon carcinoma cells transduced to secrete
interleukin (IL)-12 but do not reject similarly transduced TSA mammary adenocarcinoma …
interleukin (IL)-12 but do not reject similarly transduced TSA mammary adenocarcinoma …
IFN‐γ‐independent synergistic effects of IL‐12 and IL‐15 induce anti‐tumor immune responses in syngeneic mice
A Comes, ED Carlo, P Musiani, O Rosso… - European journal of …, 2002 - Wiley Online Library
Abstract IL‐15 and IL‐12 display anti‐tumor activity in different models and IFN‐γ has been
reported as a secondary mediator of both IL‐12 and IL‐15 effects. TS/A murine …
reported as a secondary mediator of both IL‐12 and IL‐15 effects. TS/A murine …
Role of IL-13 in regulation of anti-tumor immunity and tumor growth
M Terabe, JM Park, JA Berzofsky - Cancer Immunology, Immunotherapy, 2004 - Springer
Major mediators of anti-tumor immunity are CD4+ T h 1 cells and CD8+ cytotoxic T
lymphocytes (CTLs). In tumor-bearing animals, the T h 1-and CTL-mediated anti-tumor …
lymphocytes (CTLs). In tumor-bearing animals, the T h 1-and CTL-mediated anti-tumor …