Objective—Liver X receptor (LXR) activators decrease atherosclerosis in mice. LXR
activators (1) directly upregulate genes involved in reverse cholesterol transport and (2) …

Background—Liver X receptors (LXRs) are ligand-activated transcription factors involved in
the control of lipid metabolism and inflammation. Synthetic LXR agonists have been shown …

Background—The nuclear liver X receptor-α (LXR-α) has been implicated in the regulation
of intracellular cholesterol homeostasis, inflammatory response, and atherosclerosis …

Liver X receptors (LXR) are oxysterol-activated nuclear receptors that play a central role in
reverse cholesterol transport through up-regulation of ATP-binding cassette transporters …

Objective—Complications of atherosclerotic cardiovascular disease due to elevated blood
cholesterol levels are the major cause of death in the Western world. The liver X receptors …

Although a range of studies indicated Liver X receptor (LXR) activation inhibited the
development of atherosclerosis in animal models, the mechanism of this effect for LXR …

Background The nuclear receptor liver X receptor (LXR) has two isoforms: LXRα and LXRβ.
LXR activation promotes cholesterol efflux in macrophages, but the relative importance of …

Objective—We previously reported that a systemic liver X receptor (LXR) agonist promoted
macrophage reverse-cholesterol transport (mRCT) in vivo. Because LXR are expressed in …

Recent studies have identified the liver X receptors (LXRα and LXRβ) as important
regulators of cholesterol metabolism and transport. LXRs control transcription of genes …

Objective—Activation of liver X receptor (LXR) inhibits atherosclerosis but induces
hypertriglyceridemia. In vitro, it has been shown that mitogen-activated protein kinase kinase …