Prion-like spread of protein aggregates in neurodegeneration
M Polymenidou, DW Cleveland - Journal of Experimental Medicine, 2012 - rupress.org
Protein misfolding is common to most neurodegenerative diseases, including Alzheimer's
and Parkinson's diseases. Recent work using animal models with intracellular α-synuclein …
and Parkinson's diseases. Recent work using animal models with intracellular α-synuclein …
The propagation of prion-like protein inclusions in neurodegenerative diseases
M Goedert, F Clavaguera, M Tolnay - Trends in neurosciences, 2010 - cell.com
The most common neurodegenerative diseases, including Alzheimer's disease and
Parkinson's disease, are characterized by the misfolding of a small number of proteins that …
Parkinson's disease, are characterized by the misfolding of a small number of proteins that …
Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies
Neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, are
characterized by the abnormal aggregation of a small number of intracellular proteins, with …
characterized by the abnormal aggregation of a small number of intracellular proteins, with …
Protein aggregate spreading in neurodegenerative diseases: problems and perspectives
Progressive accumulation of specific protein aggregates is a defining feature of many major
neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, fronto …
neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, fronto …
Cell-to-cell transmission of non-prion protein aggregates
Neurodegenerative disorders such as Alzheimer disease, Parkinson disease,
frontotemporal dementia, Huntington disease and Creutzfeldt–Jakob disease (CJD) are …
frontotemporal dementia, Huntington disease and Creutzfeldt–Jakob disease (CJD) are …
Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies
M Bourdenx, NS Koulakiotis, D Sanoudou… - Progress in …, 2017 - Elsevier
Alzheimer's and Parkinson's diseases are the most prevalent neurodegenerative diseases
that generate important health-related direct and indirect socio-economic costs. They are …
that generate important health-related direct and indirect socio-economic costs. They are …
Alpha-synuclein and the prion hypothesis in Parkinson's disease
R Melki - Revue neurologique, 2018 - Elsevier
Protein intracellular inclusions within the central nervous system are hallmarks of several
progressive neurodegenerative disorders in man. The protein constituents of those deposits …
progressive neurodegenerative disorders in man. The protein constituents of those deposits …
The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration
M Costanzo, C Zurzolo - Biochemical Journal, 2013 - portlandpress.com
The misfolding and aggregation of specific proteins is a common hallmark of many
neurodegenerative disorders, including highly prevalent illnesses such as Alzheimer's and …
neurodegenerative disorders, including highly prevalent illnesses such as Alzheimer's and …
Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases
M Jucker, LC Walker - Nature neuroscience, 2018 - nature.com
Many neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive appearance of abnormal …
amyotrophic lateral sclerosis, are characterized by the progressive appearance of abnormal …
Prion-like mechanisms in neurodegenerative diseases
B Frost, MI Diamond - Nature Reviews Neuroscience, 2010 - nature.com
Many non-infectious neurodegenerative diseases are associated with the accumulation of
fibrillar proteins. These diseases all exhibit features that are reminiscent of those of …
fibrillar proteins. These diseases all exhibit features that are reminiscent of those of …