[HTML][HTML] Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells

A Qadir, S Liang, Z Wu, Z Chen, L Hu… - International journal of …, 2020 - mdpi.com
Senile osteoporosis has become a worldwide bone disease with the aging of the world
population. It increases the risk of bone fracture and seriously affects human health. Unlike …

[HTML][HTML] Osteogenesis and aging: lessons from mesenchymal stem cells

A Infante, CI Rodríguez - Stem cell research & therapy, 2018 - Springer
Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related
progressive disease characterized by reduced bone mass and increased risk of fractures. At …

[HTML][HTML] Mesenchymal progenitors in osteopenias of diverse pathologies: differential characteristics in the common shift from osteoblastogenesis to adipogenesis

B Sui, C Hu, L Liao, Y Chen, X Zhang, X Fu, C Zheng… - Scientific reports, 2016 - nature.com
Osteoporosis is caused by pathologic factors such as aging, hormone deficiency or excess,
inflammation and systemic diseases like diabetes. Bone marrow stromal cells (BMSCs), the …

[HTML][HTML] Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment

L Hu, C Yin, F Zhao, A Ali, J Ma, A Qian - International Journal of …, 2018 - mdpi.com
Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and
degraded bone microstructure, which leads to increased bone fragility and risks of bone …

[HTML][HTML] Differentiation of bone marrow mesenchymal stem cells in osteoblasts and adipocytes and its role in treatment of osteoporosis

C Wang, H Meng, X Wang, C Zhao… - … medical journal of …, 2016 - ncbi.nlm.nih.gov
Osteoporosis is a systemic metabolic bone disorder characterized by a decrease in bone
mass and degradation of the bone microstructure, leaving bones that are fragile and prone …

[HTML][HTML] Insulin impedes osteogenesis of BMSCs by inhibiting autophagy and promoting premature senescence via the TGF-β1 pathway

P Zhang, H Zhang, J Lin, T Xiao, R Xu, Y Fu… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
The dysfunction of bone marrow stromal cells (BMSCs) may be a core factor in Type 2
diabetes mellitus (T2DM) associated osteoporosis. However, the underlying mechanism is …

Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells

JO Nehlin, A Jafari, M Tencerova, M Kassem - Bone, 2019 - Elsevier
Aging is associated with decreased bone mass and accumulation of bone marrow
adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived …

[HTML][HTML] In osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis

AM Pino, CJ Rosen, JP Rodríguez - Biological research, 2012 - SciELO Chile
The formation, maintenance, and repair of bone tissue involve close interlinks between two
stem cell types housed in the bone marrow: the hematologic stem cell originating …

[HTML][HTML] Skeletal aging and osteoporosis: mechanisms and therapeutics

A Chandra, J Rajawat - International journal of molecular sciences, 2021 - mdpi.com
Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

Prospect of mesenchymal stem cells in therapy of osteoporosis: a review

L Aghebati‐Maleki, S Dolati, R Zandi… - Journal of cellular …, 2019 - Wiley Online Library
Osteoporosis is a systemic skeletal disease associated with reduced bone strong point that
results in raised fracture risk, with decreased bone strength, leading to reduced bone …