Insulin resistance and elevated triglyceride in muscle: more important for survival than 'thrifty'genes?

SR Stannard, NA Johnson - The Journal of physiology, 2004 - Wiley Online Library
Elevated intramyocellular triglyceride (IMTG) is strongly associated with insulin resistance,
though a cause and effect relationship has not been fully described. Insulin sensitivity and …

Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis* s⃞

P Zhang, L O'Loughlin, DN Brindley, K Reue - Journal of lipid research, 2008 - ASBMB
Lipin-1 deficiency in the mouse causes generalized lipodystrophy, characterized by
impaired adipose tissue development and insulin resistance. Lipin-1 expression in …

[HTML][HTML] Interrelations between fat distribution, muscle lipid content, adipocytokines, and insulin resistance: effect of moderate weight loss in older women

G Mazzali, V Di Francesco, E Zoico, F Fantin… - The American journal of …, 2006 - Elsevier
Background: Interrelations between fat distribution, muscle lipid infiltration, adipocytokines,
insulin resistance, and moderate weight loss have not been investigated in obese older …

Independent influences of central fat and skeletal muscle lipids on insulin sensitivity

SM Furler, AM Poynten, AD Kriketos, AJ Lowy… - Obesity …, 2001 - Wiley Online Library
Objective: Insulin resistance is closely associated with two disparate aspects of lipid storage:
the intracellular lipid content of skeletal muscle and the magnitude of central adipose beds …

Relationship between intermuscular adipose tissue infiltration and myostatin before and after aerobic exercise training

AR Konopka, CA Wolff, MK Suer… - American Journal of …, 2018 - journals.physiology.org
Intermuscular adipose tissue (IMAT) is associated with impaired skeletal muscle contractile
and metabolic function. Myostatin and downstream signaling proteins such as cyclin …

Intramuscular lipid metabolism, insulin action, and obesity

LA Consitt, JA Bell, JA Houmard - IUBMB life, 2009 - Wiley Online Library
With the increasing prevalence of obesity, research has focused on the molecular
mechanism (s) linking obesity and skeletal muscle insulin resistance. Metabolic alterations …

Insulin action, regional fat, and myocyte lipid: altered relationships with increased adiposity

SK Gan, AD Kriketos, AM Poynten, SM Furler… - Obesity …, 2003 - Wiley Online Library
Objective: Abdominal fat and myocyte triglyceride levels relate negatively to insulin
sensitivity, but their interrelationships are inadequately characterized in the overweight …

Dynamic transcriptome and DNA methylome analyses on longissimus dorsi to identify genes underlying intramuscular fat content in pigs

Y Wang, C Ma, Y Sun, Y Li, L Kang, Y Jiang - BMC genomics, 2017 - Springer
Background The intramuscular fat content (IMF) refers to the amount of fat within muscles,
including the sum of phospholipids mainly found in cell membranes, triglycerides and …

Triennial growth and development symposium: Molecular mechanisms related to bovine intramuscular fat deposition in the longissimus muscle

M Baik, HJ Kang, SJ Park, SW Na, M Piao… - Journal of Animal …, 2017 - academic.oup.com
The intramuscular fat (IMF) content of the LM, also known as marbling, is particularly
important in determining the price of beef in Korea, Japan, and the United States. Deposition …

Role of visceral adipose tissue in aging

DM Huffman, N Barzilai - Biochimica et Biophysica Acta (BBA)-General …, 2009 - Elsevier
BACKGROUND: Visceral fat (VF) accretion is a hallmark of aging in humans. Epidemiologic
studies have implicated abdominal obesity as a major risk factor for insulin resistance, type 2 …