p53-induced GDF-15 expression promotes a pro-regenerative response in human chondrocytes upon cartilage injury

SS Marques, A Liebaug, S Maurer, D Rothenbacher… - bioRxiv, 2024 - biorxiv.org
Posttraumatic osteoarthritis (PTOA) is a special form of OA, developing after joint injuries.
Except for some minor differences between the clinical characteristics of patients suffering …

[HTML][HTML] Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis

K Kania, F Colella, AHK Riemen, H Wang… - Scientific Reports, 2020 - nature.com
Abstract Growth and Differentiation Factor 5 (GDF5) is a key risk locus for osteoarthritis (OA).
However, little is known regarding regulation of Gdf5 expression following joint tissue …

GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury

CR Brightwell, CM Latham, AR Keeble, NT Thomas… - Science …, 2023 - science.org
Musculoskeletal disorders contribute substantially to worldwide disability. Anterior cruciate
ligament (ACL) tears result in unresolved muscle weakness and posttraumatic osteoarthritis …

[HTML][HTML] Intra-articular supplementation with recombinant human GDF5 arrests disease progression and stimulates cartilage regeneration in the rat medial meniscus …

BA Byers, WR Parrish, J Geesin… - Osteoarthritis and …, 2014 - oarsijournal.com
Purpose: Genome-wide association studies and investigation of osteoarthritis (OA) risk
alleles suggest that reduced levels of functional Growth and Differentiation Factor 5 (GDF5) …

[HTML][HTML] Role of GDF15/MAPK14 axis in chondrocyte senescence as a novel senomorphic agent in osteoarthritis

PW Weng, NW Pikatan, SA Setiawan… - International journal of …, 2022 - mdpi.com
Osteoarthritis (OA) is most prevalent in older individuals and exerts a heavy social and
economic burden. However, an effective and noninvasive approach to OA treatment is …

Growth differentiation factor 5 in cartilage and osteoarthritis: A possible therapeutic candidate

K Sun, J Guo, X Yao, Z Guo, F Guo - Cell Proliferation, 2021 - Wiley Online Library
Abstract Growth differentiation factor 5 (GDF‐5) is essential for cartilage development and
homeostasis. The expression and function of GDF‐5 are highly associated with the …

Modulatory effects of inflammation and therapy on GDF‐5 expression in rheumatoid arthritis synovium

CP Bramlage, C Kaps, U Ungethüm… - Scandinavian journal …, 2008 - Taylor & Francis
Objective: Growth differentiation factor‐5 (GDF‐5), a member of the transforming growth
factor (TGF)‐β family, is involved in joint development during embryogenesis and has the …

Expression of growth and differentiation factor 5 during joint repair and osteoarthritis

K Kania, F Colella, AH Riemen, H Wang… - Osteoarthritis and …, 2020 - oarsijournal.com
Purpose: Growth and differentiation factor 5 (GDF5) is a key risk locus for osteoarthritis (OA),
with single-nucleotide polymorphisms that result in decreased GDF5 expression contributing …

GDF-5 is suppressed by IL-1β and enhances TGF-β3-mediated chondrogenic differentiation in human rheumatoid fibroblast-like synoviocytes

FL Liu, LH Lin, HK Sytwu, DM Chang - Experimental and molecular …, 2010 - Elsevier
OBJECTIVE: To investigate the expression of growth differentiation factor-5 (GDF-5) in
chondrocytes (HC) and fibroblast-like synoviocytes (FLS) from humans with rheumatoid …

GDF5 modifies disease in OA rat model

J McHugh - Nature Reviews Rheumatology, 2017 - nature.com
Growth and differentiation factor 5 (GDF5) could halt and reverse osteoarthritis (OA)
progression, according to a new study published in Osteoarthritis and Cartilage …