Central 5-HT2 and 5-HT1C receptors appear to be relatively resistant to up-regulation. 5-
HT2 receptors are not upregulated after denervation of 5-HT neurons and chronic …

The hypothesis that serotonin (5-HT)-stimulated phosphoinositide hydrolysis is mediated by
the 5-HT-2 binding site in cerebral cortex was tested by comparing antagonist Kd values …

Serotonin (5‐hydroxytryptamine; 5‐HT) 5‐HT2A and 5‐HT2C receptors belong to the class
of phosphoinositide‐specific phospholipase C (PLC)‐linked receptors. Conditions were …

SUMMARY A permanent line of cells has been established from the trans-plantable rat
pituitary tumor 731 5a. P1 1 cells have been cloned repeatedly, and after more than 60 …

Numerous investigations have studied in vivo regulation of central 5-HT2A receptors. The
majority of pharmacological studies point to non-classical regulation of this site …

SUMMARY The 5-hydroxytryptamine(5-HT) 2 receptor is a G protein-coupled receptor that
exhibits constitutive receptor activation, defined as agonist-independent receptor activation …

Both the 5-hydroxytryptamine2 (5-HT2) and 5-HT1c receptors may be regulated by a large
number of endogenous and exogenous factors. The 5-HT2 receptors, for example, may be …

Abstract A serotonin (5-HT)-mediated phosphoinositide hydrolysis response was
characterized in fibroblasts cultured from rabbit choroid plexus. 5-HT elicited a maximum 8 …

Adaptive changes in the serotonergic system are generally believed to underlie the
therapeutic effectiveness of the azapirone anxiolytics and a variety of antidepressant drugs …

This study confirms and extends an earlier report that acute administration of the serotonin
(5-HT) antagonist, mianserin, caused a marked decrease, in the density of 5-HT 2 binding …