Metabolite profiling in blood plasma
Metabolite profiling has been established as a multiparallel strategy for relative
quantification of a mixture of compounds or compound classes using chromatography and …
quantification of a mixture of compounds or compound classes using chromatography and …
Gas chromatography-mass spectrometry (GC-MS)-based metabolomics
Metabolic fingerprinting, the main tool in metabolomics, is a non-targeted methodology
where all detectable peaks (or signals), including those from unknown analytes, are …
where all detectable peaks (or signals), including those from unknown analytes, are …
Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry
WB Dunn, D Broadhurst, P Begley, E Zelena… - Nature protocols, 2011 - nature.com
Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …
Metabolite profiling of a NIST Standard Reference Material for human plasma (SRM 1950): GC-MS, LC-MS, NMR, and clinical laboratory analyses, libraries, and web …
Y Simón-Manso, MS Lowenthal, LE Kilpatrick… - Analytical …, 2013 - ACS Publications
Recent progress in metabolomics and the development of increasingly sensitive analytical
techniques have renewed interest in global profiling, ie, semiquantitative monitoring of all …
techniques have renewed interest in global profiling, ie, semiquantitative monitoring of all …
New sample preparation approach for mass spectrometry-based profiling of plasma results in improved coverage of metabolome
Y Yang, C Cruickshank, M Armstrong… - … of chromatography A, 2013 - Elsevier
Sample preparation remains a challenge in untargeted metabolomics studies and no
method currently results in complete extraction of all metabolite classes in human plasma …
method currently results in complete extraction of all metabolite classes in human plasma …
Evaluation of a protocol for metabolic profiling studies on human blood plasma by combined ultra-performance liquid chromatography/mass spectrometry: From …
The investigation presented here describes a protocol designed to perform high-throughput
metabolic profiling analysis on human blood plasma by ultra-performance liquid …
metabolic profiling analysis on human blood plasma by ultra-performance liquid …
Mass spectrometry-based non-targeted metabolic profiling for disease detection: recent developments
X Zang, ME Monge, FM Fernandez - TrAC Trends in Analytical Chemistry, 2019 - Elsevier
Mass spectrometry (MS) plays an important role in seeking biomarkers for disease detection.
High-quality quantitative data is needed for accurate analysis of metabolic perturbations in …
High-quality quantitative data is needed for accurate analysis of metabolic perturbations in …
Liquid chromatography–mass spectrometry based global metabolite profiling: a review
Untargeted, global metabolite profiling (often described as metabonomics or metabolomics)
represents an expanding research topic and is, potentially, a major pillar for systems biology …
represents an expanding research topic and is, potentially, a major pillar for systems biology …
From differentiating metabolites to biomarkers
A Koulman, GA Lane, SJ Harrison… - Analytical and bioanalytical …, 2009 - Springer
The current developments in metabolomics and metabolic profiling technologies have led to
the discovery of several new metabolic biomarkers. Finding metabolites present in …
the discovery of several new metabolic biomarkers. Finding metabolites present in …
Strategies and challenges in method development and validation for the absolute quantification of endogenous biomarker metabolites using liquid chromatography …
Metabolomics is a dynamically evolving field, with a major application in identifying
biomarkers for drug development and personalized medicine. Numerous metabolomic …
biomarkers for drug development and personalized medicine. Numerous metabolomic …